AMPK信号通路在糖尿病心肌病中的研究进展

发布时间：2018-03-15 23:13

本文选题：AMPK　切入点：能量代谢　出处：《中国药理学通报》2017年11期 　论文类型：期刊论文

【摘要】：AMP依赖的蛋白激酶(AMPK)是调节生物能量恒定性的重要传感分子,能激活上游激酶LKB1、Ca MKKβ和Tak1等。AMP/ATP比值可调节AMPK的活性,从而控制能量代谢的分解与合成通路,骨骼肌收缩与心肌缺血时能够激活AMPK,调节脂肪细胞的代谢和血管功能,促进葡萄糖转运和脂肪酸氧化。排除动脉粥样硬化、高血压及其他潜在病因,由糖尿病引发的心肌结构与功能异常的一种独立的原发病,称之为糖尿病心肌病,可引起患者死亡。由于血糖水平、脂肪酸氧化和糖原代谢受AMPK的调节,因此,在DCM形成过程中AMPK起着至关重要的作用。该文综述了AMPK信号通路在糖尿病心肌病发生、发展过程中的作用。
[Abstract]:AMP dependent protein kinase (AMPK) is an important sensing molecule regulating the stability of biological energy. It can activate the ratio of upstream kinase LKB1Ca MKK 尾 and Tak1 to regulate the activity of AMPK, thus controlling the catabolism and synthesis pathway of energy metabolism. Skeletal muscle contraction and myocardial ischemia can activate AMPK, regulate adipocyte metabolism and vascular function, promote glucose transport and fatty acid oxidation, and exclude atherosclerosis, hypertension and other underlying causes. An independent primary disease, called diabetic cardiomyopathy, that causes death in patients with abnormal myocardial structure and function caused by diabetes. Because blood sugar levels, fatty acid oxidation and glycogen metabolism are regulated by AMPK, AMPK plays an important role in the formation of DCM. This article reviews the role of AMPK signaling pathway in the pathogenesis and development of diabetic cardiomyopathy.
【作者单位】：糖尿病心脑血管病变湖北省重点实验室湖北科技学院医药研究院;
【基金】：国家自然科学基金资助项目(No 51703055) 湖北省自然科学基金资助项目(No 2017CFB699,2015CFC773) 湖北省教育厅科学研究计划项目(No B201696) 湖北科技学院糖尿病专项基金项目(No 2016-18XZ09,14ZX-02)
【分类号】：R542.2;R587.2

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