慢性苯中毒患者脱离苯接触后外周血淋巴细胞微核率与血常规指标变化特征

发布时间：2018-03-16 11:16

  本文选题：慢性苯中毒　切入点：血常规　出处：《环境与职业医学》2017年05期 　论文类型：期刊论文

【摘要】：[目的]研究慢性苯中毒患者脱离苯接触2~48年后,血常规指标与外周血淋巴细胞微核率变化特征,及二者关系。[方法]以上海市某医院诊断的36例慢性苯中毒患者(确诊后均脱离苯接触)为病例组,按照性别、年龄匹配在社区选择36名健康者作为对照组。对72名研究对象进行血常规检测,并采用胞质分裂阻滞微核实验检测微核率。分别用配对t检验、Poisson回归比较病例组和对照组的血常规结果和微核率,用趋势性检验分析病例组血常规结果与微核率之间的关系,用卡方检验分析微核异常率,用logistic回归模型分析微核率异常的影响因素。[结果]与对照组相比,病例组的白细胞计数下降了1.95×10~9/L、中性粒细胞下降了0.85×10~9/L、淋巴细胞下降了0.7×10~9/L、红细胞计数下降了0.39×10~(12)/L、血红蛋白下降了9.21 g/L及血小板下降了50.17×10~(12)/L,差异均具有统计学意(P0.01);病例组白细胞异常率、中性粒细胞异常率、血红蛋白异常率与对照组差异具有统计学意义(χ~2=20.67,P0.001;χ~2=12.77,P0.001;χ~2=11.61,P=0.001);病例组和对照组的外周血淋巴细胞微核率分别为(7.22±2.87)‰和(4.14±1.66)‰,病例组微核率比对照组升高74%(FR=1.74,P0.001)。白细胞、中性粒细胞均与微核率呈负相关,Spearman相关系数分别为-0.416、-0.495(P0.05,P0.01)。病例组18例当前白细胞正常者(≥4.0×10~9/L且≤10.0×10~9/L),其微核率仍高于配对对照组(FR=1.40,P0.05)。病例组按脱离苯接触年数分组,与对照组相比,随着脱离年数的增加,三组微核率均升高(FR=1.46,P=0.025;FR=1.92,P0.001;FR=1.79,P0.001)。三组微核率异常的风险有升高趋势(OR=4.05,P=0.153;OR=27.33,P=0.001;OR=355.26,P=0.001)。[结论]慢性苯中毒患者脱离苯接触后仍会持续存在血液毒性与遗传毒性,微核率比白细胞更加敏感。
[Abstract]:[objective] to study the changes of blood routine indexes and micronucleus rate of peripheral blood lymphocytes in patients with chronic benzene poisoning after 2 ~ 48 years of exposure to benzene. [methods] 36 cases of chronic benzene poisoning diagnosed by a hospital in Shanghai were selected as the case group. Age matching selected 36 healthy people as the control group in the community. Blood routine examination was performed on 72 subjects. The micronucleus rate was detected by cytokinesis block micronucleus test. The blood routine results and micronucleus rates were compared by paired t test Poisson regression, and the relationship between blood routine results and micronucleus rate was analyzed by trend test. The abnormal rate of micronucleus was analyzed by chi-square test and the influencing factors of abnormal rate of micronucleus were analyzed by logistic regression model. [results] compared with the control group, In the case group, the leukocyte count decreased by 1.95 脳 10 ~ (9) / L, the neutrophils decreased by 0.85 脳 10 ~ (9) / L, the lymphocytes decreased by 0.7 脳 10 ~ (9) / L, the erythrocyte count decreased by 0.39 脳 10 ~ (10) / L, the hemoglobin decreased by 9.21 g / L, and the platelet decreased by 50.17 脳 10 ~ (12) / L, the difference was statistically significant. The abnormal rate of neutrophil and hemoglobin were significantly different from those of the control group (蠂 ~ 2 ~ 2n ~ (20. 67) P _ (0.001); 蠂 ~ (2 +) ~ (2)) ~ (12.77) P _ (0.001); 蠂 ~ (2 +) ~ (2) C ~ (11.61) P ~ (0.001); the micronucleus rate of peripheral blood lymphocytes in the case group and the control group were 7.22 卤2.87 鈥，

本文编号：1619676