腰椎局部注射唑来膦酸对骨质疏松兔椎体骨形成的影响

发布时间：2018-03-17 04:18

本文选题：骨质疏松症　切入点：唑来膦酸　出处：《山东医药》2016年32期 　论文类型：期刊论文

【摘要】：目的探讨腰椎局部注射唑来膦酸对骨质疏松兔椎体骨形成的影响。方法将24只骨质疏松模型兔(去势法制备)随机分为观察组与模型组,各12只。观察组于L4椎体侧方注入唑来膦酸0.4 mg,模型组只穿刺,不注药。处理后4、8、12周两组各随机处死4只,取出L4椎体,比较两组各时间点骨小梁数量、骨皮质厚度、椎体骨密度(BMD)、骨小梁相关参数[骨小梁厚度(Tb Th)、骨小梁数量(Tb N)、相对骨体积(BV/TV)、骨小梁间隙(Tb Sp)]及组织病理情况。结果处理后随着时间延长,骨小梁数量逐渐增多,骨皮质逐渐增厚。处理后4、8、12周,观察组椎体BMD、Tb Th、Tb N、BV/TV逐渐升高,Tb Sp逐渐降低;模型组椎体BMD、Tb Th、Tb N、BV/TV逐渐降低,Tb Sp逐渐升高。处理后4、8、12周观察组BMD、Tb Th、Tb N、BV/TV均高于模型组,Tb Sp均低于模型组(P均0.05)。组织病理检查显示,观察组较模型组骨皮质增厚,成骨细胞增多;骨小梁增粗,数量增加,分布较规律,连续性更好。结论腰椎局部注射唑来膦酸有助于骨质疏松兔的椎体骨形成。
[Abstract]:Objective to investigate the effect of local injection of zoledronic acid on vertebral bone formation in osteoporotic rabbits. Methods 24 osteoporosis model rabbits were randomly divided into observation group and model group. 12 rats in each group were injected with zoledronic acid 0.4 mg on the side of L4 vertebra, and 4 rats were randomly killed in the model group at 812 weeks after treatment. The number of trabecular bone and the thickness of bone cortex were compared between the two groups at each time point. Bone mineral density (BMD), trabeculae related parameters (thickness of trabecular bone, quantity of trabecular bone, relative volume of bone (BV / TVV), trabecular space (TB Span)) and histopathology were measured. Results the number of trabeculae increased with time after treatment. The thickening of the bone cortex gradually increased and the TbSp decreased gradually in the observation group after treatment for 8 weeks and 12 weeks after treatment, and the level of TbSp in the observation group was gradually increased and the TbSp was gradually decreased. The TbSp in the model group was lower than that in the model group, and the TbSp in the observation group was higher than that in the model group at 812 weeks after treatment. The histopathological examination showed that the bone cortex thickened and osteoblasts increased in the observation group compared with the model group. Conclusion Local injection of zoledronic acid to lumbar vertebrae is helpful to the formation of vertebral body in osteoporotic rabbits.
【作者单位】：皖南医学院附属铜陵市人民医院;皖南医学院;
【基金】：铜陵市卫生局基金资助项目(卫科研[2012]12)
【分类号】：R580

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