1228例健康人群血清CTX-1、TRACP、BALP、OC水平与腰椎骨密度的相关性

发布时间：2018-03-17 16:12

本文选题：骨代谢标志物　切入点：Ⅰ型胶原交联C-末端肽　出处：《中国骨质疏松杂志》2016年08期 　论文类型：期刊论文

【摘要】：目的研究30~79岁健康人群不同年龄、不同性别Ⅰ型胶原交联C-末端肽(CTX-1)、抗酒石酸酸性磷酸酶(TRACP)、骨碱性磷酸酶(BALP)、骨钙素(OC)与腰椎骨密度(bone mineral density,BMD)的相关性。方法采用Hologic Discovery WA型骨密度仪检测腰椎正位(L1-4)BMD,采用酶标免疫分析仪检测血清CTX-1、TRACP、BALP、OC水平。将1228例受试者的检测结果按不同性别、10岁为1个年龄段进行分组,应用SPSS 19.0软件进行统计分析。结果女性30~49岁年龄段CTX-1、TRACP、BALP、OC与腰椎BMD均无明显相关性,50岁以后CTX-1、TRACP显著升高,与BMD呈负相关。女性BALP、OC在50~59岁年龄段明显升高,与BMD负相关,60岁以后开始下降,与BMD呈正相关;男性30~59岁各年龄组CTX-1、TRACP、BALP与腰椎BMD均无相关性,60岁以后CTX-1、TRACP、BALP均明显升高,与BMD负相关。男性OC水平随年龄缓慢下降,但各年龄段与BMD均无相关性;在30~49岁年龄段TRACP、CTX-1、BALP、OC各指标性别间不存在差异,50岁以后同年龄组性别间差异有统计学意义(P0.05),且女性高于男性。结论 TRACP、CTX-1、BALP、OC是监测骨代谢变化的重要技术手段,尤其对女性骨质疏松具有较高的敏感性和特异性。
[Abstract]:Objective to study the different ages of healthy people aged 30 to 79 years, The correlation between type I collagen cross-linked C-terminal peptide CTX-1, tartrate-resistant acid phosphatase (TRACPP), bone alkaline phosphatase (BALP), osteocalcin (OC) and bone mineral density (BMD) of lumbar vertebrae was determined by Hologic Discovery WA type BMD. The serum levels of CTX-1TRACPP BALPOC were detected by Elisa. The results of 1228 subjects were divided into 1 age group according to different sex and 10 years old. Results there was no significant correlation between CTX-1TRAP and BMD of lumbar vertebrae in women aged 30 to 49. After 50 years of age, CTX-1 was significantly increased, but negatively correlated with BMD, while female BALPOC was significantly increased in the age group of 50 to 59 years. There was no correlation between CTX-1TRACPBALP and BMD of lumbar vertebrae, but there was a negative correlation between BMD and CTX-1TRACPBALP. The level of OC decreased slowly with age. But there was no correlation between age and BMD. There was no difference among the sex indexes of TRACPCTX-1 BALPU OC in the age group of 30 to 49 years old. There was significant difference between the sexes of the same age group after 50 years old, and the female was higher than that of the male. Conclusion TRACPCPX CTX-1 BALPOC is an important technique for monitoring the changes of bone metabolism. Especially for female osteoporosis has a high sensitivity and specificity.
【作者单位】：吉林省骨质疏松诊疗中心(吉林大学第四医院);
【分类号】：R580

【相似文献】