血清IgG4在不同疾病患者中的表达

发布时间：2018-03-18 00:40

  本文选题：IgG　切入点：IgG相关性疾病　出处：《北京大学学报(医学版)》2017年06期 　论文类型：期刊论文

【摘要】：目的:探讨血清IgG4在不同疾病患者中的表达,以及其在IgG4相关性疾病患者治疗前后的变化和临床意义。方法:选择北京大学人民医院2015年1月1日至2016年3月31日就诊患者中进行血清IgG4检验的620例患者为研究对象进行回顾性分析,按照病种的不同分为普通疾病组、自身免疫性疾病组及IgG4相关性疾病组;胰腺疾病患者分为自身免疫性胰腺炎组及胰腺癌组;按照疾病治疗阶段不同将IgG4相关性疾病患者再分为治疗前组及治疗后组;分别分析对比各组患者血清IgG4的表达。结果:普通疾病组的患者血清IgG4水平中位数为0.480(0.005,50.400)g/L,自身免疫性疾病组患者血清IgG4水平中位数为0.406(0.003,18.700)g/L,IgG4相关性疾病组患者血清IgG4水平中位数为5.200(0.046,46.000)g/L,明显高于普通疾病组及自身免疫性疾病组,与该两组患者血清IgG4水平差异有统计学意义(P0.01),普通疾病组与自身免疫性疾病组患者血清IgG4水平相比,差异无统计学意义(P0.05)。胰腺疾病患者中,自身免疫性胰腺炎组患者血清IgG4水平中位数为3.735(0.063,46.000)g/L,胰腺癌组患者血清IgG4水平中位数为0.438(0.056,1.130)g/L,自身免疫性胰腺炎组患者血清IgG4水平高于胰腺癌组,差异具有统计学意义(P0.01)。在IgG4相关性疾病患者中,治疗前患者组血清IgG4水平中位数为6.540(1.330,34.100)g/L,治疗后患者组血清IgG4水平中位数为3.705(0.208,30.200)g/L,血清IgG4水平在患者治疗后下降,低于治疗前水平,差异具有统计学意义(P0.01)。结论:不同疾病类型的患者血清IgG4表达不同,在自身免疫性胰腺炎及IgG4相关性疾病中,患者血清IgG4表达明显升高,通过检测患者血清IgG4水平的高低,可以为不同疾病的鉴别诊断提供依据;在IgG4相关性疾病中,血清IgG4水平在治疗后表达明显下降,血清IgG4有可能作为评估IgG4相关性疾病疗效的指标之一。
[Abstract]:Objective: to investigate the expression of serum IgG4 in patients with different diseases. The changes and clinical significance of IgG4 in patients with IgG4 associated diseases before and after treatment methods: a total of 620 patients with serum IgG4 were selected from January 1st 2015 to March 31st 2016 in Peking University Renmin Hospital. The research object carries on the retrospective analysis, Patients with pancreatic diseases were divided into three groups: common disease group, autoimmune disease group and IgG4 associated disease group, and pancreatic disease patients were divided into autoimmune pancreatitis group and pancreatic cancer group. Patients with IgG4 related diseases were subdivided into pre-treatment group and post-treatment group according to the stage of disease treatment. Results: the median level of serum IgG4 in patients with common diseases was 0.480,0.005 ~ 50.400 g / L, and the median of serum IgG4 in autoimmune diseases was 0.406 ~ 0.003 ~ 18.700 g 路L ~ (-1) L ~ (-1). Results: the median of serum IgG4 was 0.406g / L of 18.700g / L IgG4-associated diseases. The average median was 5.200 g / L of 0.046 g / L, which was significantly higher than that of the general disease group and the autoimmune disease group. There was a significant difference in serum IgG4 level between the two groups (P 0.01), but there was no significant difference in serum IgG4 level between the normal disease group and the autoimmune disease group (P 0.05). The median of serum IgG4 level in autoimmune pancreatitis group was 3.735 卤0.063 GPA / L, and the median serum IgG4 level in pancreatic cancer group was 0.438 / 0.056 / L and 1.130 g / L, respectively. The serum IgG4 level in autoimmune pancreatitis group was higher than that in pancreatic cancer group, and the serum IgG4 level in autoimmune pancreatitis group was higher than that in pancreatic carcinoma group. In the patients with IgG4 related diseases, the median of serum IgG4 level before treatment was 6.540 / 1.330, 34.100g / L, and after treatment the median level of serum IgG4 was 3.7050.2080.200 g / L, and the level of serum IgG4 decreased after treatment, which was lower than that before treatment. Conclusion: the expression of serum IgG4 is different in patients with autoimmune pancreatitis and IgG4 related diseases. The expression of IgG4 in serum of patients with autoimmune pancreatitis and IgG4 related diseases is obviously increased. It can provide evidence for differential diagnosis of different diseases, in IgG4 related diseases, the expression of serum IgG4 decreased significantly after treatment, serum IgG4 may be one of the indicators to evaluate the curative effect of IgG4 related diseases.
【作者单位】： 北京大学人民医院消化内科;郑州人民医院消化内科;
【分类号】：R593.2

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