血清肿瘤坏死因子-α及白细胞介素-18水平与2型糖尿病患者大血管病变的关系

发布时间：2018-03-21 20:20

本文选题：型糖尿病　切入点：大血管病变　出处：《中国老年学杂志》2016年14期 　论文类型：期刊论文

【摘要】：目的探讨血清肿瘤坏死因子(TNF)-α及白细胞介素(IL)-18水平与2型糖尿病(T2DM)患者大血管病变的关系。方法选择2014年1月至2015年1月T2DM住院患者60例,依据是否存在大血管病变分为T2DM组26例和T2DM大血管病变(T2DM-M)组34例,选择同期健康体检者50例为对照组,检测各组血糖血脂相关指标、TNF-α及IL-18水平。结果 T2DM和T2DM-M组TNF-α和IL-18水平均显著高于对照组,且T2DM大血管病变组高于T2DM组(均P0.05);T2DM组和T2DM-M组空腹血糖(FPG)、糖化血红蛋白(Hb A1c)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平均显著高于对照组,高密度脂蛋白胆固醇(HDL-C)水平显著低于对照组(均P0.05);T2DM-M组的FPG、Hb A1c、TG显著高于T2DM组(均P0.05)。Logistic回归分析显示TNF-α和IL-18为T2DM大血管病变的独立危险因素。结论血清TNF-α和IL-18共同参与了T2DM患者大血管病变过程,降低血清TNF-α和IL-18水平有助于预防和改善大血管病变程度。
[Abstract]:Objective to investigate the relationship between the serum levels of TNF- 伪 and IL-IL-18 and macroangiopathy in patients with type 2 diabetes mellitus (T2DM). Methods 60 patients with T2DM from January 2014 to January 2015 were selected. According to the existence of macrovascular disease, 26 cases in T2DM group and 34 cases in T2DM-M group in T2DM group were divided into two groups. 50 healthy persons were selected as control group. Results the levels of TNF- 伪 and IL-18 in the T2DM and T2DM-M groups were significantly higher than those in the control group. The levels of fasting blood glucose (FBG), HbA1C, triglyceride (TG), low density lipoprotein cholesterol (LDL-C) in T2DM macroangiopathy group were significantly higher than those in T2DM group (P0.05 T2DM group and T2DM-M group). High density lipoprotein cholesterol (HDL-C) level was significantly lower than that in control group (all P0.05T2DM-M group was significantly higher than that in T2DM group (all P0.05).Logistic regression analysis showed that TNF- 伪 and IL-18 were independent risk factors for T2DM macroangiopathy. Conclusion Serum TNF- 伪 and IL-18 are involved in this study. The process of macroangiopathy in patients with T2DM, Lowering the serum levels of TNF- 伪 and IL-18 is helpful to prevent and improve the degree of macroangiopathy.
【作者单位】：华中科技大学同济医学院附属武汉市中心医院内分泌科;
【基金】：国家自然科学基金项目(No.31400916)
【分类号】：R587.2;R543

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