益肾化湿颗粒联合舒洛地特对早期老年糖尿病肾病氧化应激及内皮功能的影响

发布时间：2018-03-22 01:14

本文选题：糖尿病肾病　切入点：益肾化湿颗粒　出处：《中国实验方剂学杂志》2016年05期 　论文类型：期刊论文

【摘要】：目的:观察益肾化湿颗粒联合舒洛地特对早期老年糖尿病肾病(DN)氧化应激及内皮功能的影响。方法:86例早期糖尿病肾病患者随机分成两组,两组均给予常规治疗,对照组加用舒洛地特注射液肌肉注射600 LSU(酯酶单位),1次·d~(-1),连续治疗2周后,口服舒洛地特软胶囊,1粒/次,2次/d,连续治疗4个月。观察组在对照组治疗的基础上加用益肾化湿颗粒,10 g·次-1,3次/d。连续治疗4个月。观察治疗前后血糖,血肌酐(SCr),超氧化物歧化酶(SOD),丙二醛(MDA),血管性血友病因子(v WF),内皮素(ET)-1以及24 h尿白蛋白排泄率(24 h UAER)。结果:与治疗前比较,两组24 h UAER和SCr水平明显下降(P0.05,P0.01),尤其观察组更加明显[分别为(72.3±15.8)mg·(24 h)-1,(65.8±20.6)μmol·L~(-1)],与对照组[分别为(87.6±17.2)mg·(24 h)-1,(91.6±23.8)μmol·L~(-1)]比较差异有统计学意义(均P0.05)。治疗后观察组MDA,v WF,ET-1[分别为(4.01±0.4)μmol·L~(-1),(159.5±26.4)%,(55.7±7.2)ng·L~(-1)]较治疗前明显下降(均P0.05),与对照组[分别为(5.31±0.51)μmol·L~(-1),(181.3±28.2)%,(60.4±7.5)ng·L~(-1)]比较差异有统计学意义(P0.05)。治疗后观察组SOD[(129.3±7.1)U·m L~(-1)]较治疗前明显上升(P0.05),与对照组[(70.2±4.5)U·m L~(-1)]比较差异有统计学意义(P0.05)。结论:益肾化湿颗粒具有较强抗氧化作用,能有效的延缓血管内皮的损伤,减少蛋白尿的排出,而且联合舒洛地特共同治疗,调节血管内皮功能的效果更加明显,延缓早期DN发展。
[Abstract]:Objective: to observe the effect of Yishen Huashi granule combined with sulodide on oxidative stress and endothelial function in early aged diabetic nephropathy patients. Methods: 86 patients with early diabetic nephropathy were randomly divided into two groups. In the control group, sulodite injection was injected intramuscularly into the control group with 600 LSUA (Esterase unit) once a day, and after 2 weeks of continuous treatment, The patients in the observation group were treated with 10 g of Yishen Huashi granule (10 g / d) and 3 times / d for 4 months. The blood glucose was observed before and after treatment. Serum creatinine, superoxide dismutase (SOD), malondialdehyde (MDA), von Willebrand factor (VHD), endothelin (et) -1 and 24 h urinary albumin excretion rate (24 h UAERA) were compared with those before treatment. The levels of UAER and SCr in the two groups decreased significantly at 24 h, especially in the observation group (72.3 卤15.8)mg 24 h, 65.8 卤20.6 渭 mol / L), and were significantly higher than those in the control group [87.6 卤17.2)mg 24 h, 91.6 卤23.8) 渭 mol L ~ (-1)] (P0.05). After treatment, MDA-vWFET-1 [4.01 卤0.4 渭 mol] was significantly higher than that of the control group (P < 0.05). There was a significant difference between the two groups (all P0.05U, P 0.05U, compared with the control group [181.3 卤28.2U mol / L, 181.3 卤28.2U / L, 60.4 卤7.5)ng / L)]. The SOD of the observation group [129.3 卤7.1U mL / L] was significantly higher than that of the control group [70.2 卤4.5U / ml]. Conclusion: there is a significant difference between the observation group (129.3 卤7.1U mL / L) and the control group (70.2 卤4.5U / ml). Conclusion: there is a significant difference between the observation group and the control group [70.2 卤4.5U / ml]. Conclusion: after treatment, the SOD in the observation group is significantly higher than that in the control group [129.3 卤7.1U mL / L ~ (-1)]. Strong antioxidant activity, It can effectively delay the injury of vascular endothelium, reduce the excretion of proteinuria, and combined with sulodide, the effect of regulating vascular endothelial function is more obvious, delaying the development of early DN.
【作者单位】：漯河市第二人民医院;
【分类号】：R587.2

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