地屈孕酮片治疗更年期综合征的临床研究

发布时间：2018-03-22 11:51

本文选题：地屈孕酮片　切入点：更年期综合征　出处：《中国临床药理学杂志》2017年23期 　论文类型：期刊论文

【摘要】：目的观察地屈孕酮片治疗更年期综合征的临床疗效及安全性。方法将86例更年期综合征妇女随机分为对照组43例和试验组43例。对照组予以安慰剂每次10 mg,qd,口服;试验组予以地屈孕酮每次10 mg,qd,口服。2组患者均治疗1个月。比较2组患者的临床疗效、性激素和血脂水平,以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为93.02%(40例/43例)和72.09%(31例/43例),差异有统计学意义(P0.05)。治疗后,试验组和对照组的促黄体生成素分别为(11.70±1.13)和(28.36±4.48)U·L~(-1),促卵泡生长激素分别为(36.31±4.24)和(60.77±7.75)U·L~(-1),雌二醇分别为(71.76±9.37)和(45.43±5.21)pmol·L~(-1),三酰甘油分别为(1.23±0.24)和(1.72±0.20)mmol·L~(-1),总胆固醇分别为(4.94±0.66)和(5.82±0.58)mmol·L~(-1),低密度脂蛋白胆固醇分别为(2.64±0.36)和(3.25±0.31)mmol·L~(-1),高密度脂蛋白胆固醇分别为(1.66±0.21)和(1.38±0.13)mmol·L~(-1),差异均有统计学意义(均P0.05)。试验组出现失眠及头痛各2例次,对照组未发生药物不良反应。试验组和对照组的总药物不良反应发生率分别为9.30%和0,差异无统计学意义(P0.05)。结论地屈孕酮片治疗更年期综合征妇女的临床疗效确切,其能够有效调节血脂和性激素水平,且不增加药物不良反应的发生率。
[Abstract]:Objective to observe the clinical efficacy and safety of Diproprogesterone tablets in the treatment of climacteric syndrome. Methods 86 women with menopausal syndrome were randomly divided into control group (n = 43) and experimental group (n = 43). The patients in the trial group were treated with diproprogesterone at a dose of 10 mg / g QD for one month. The clinical efficacy, sex hormone and blood lipid levels, and adverse drug reactions were compared between the two groups. The total effective rates of the test group and the control group were 93.02% and 72.09%, respectively, and there were 31 / 43 cases in the control group. The difference was statistically significant (P 0.05). Luteinizing hormone was 11.70 卤1.13), follicular growth hormone was 36.31 卤4.24) and follicle growth hormone was 60.77 卤7.75 U Ln-1, estradiol was 71.76 卤9.37) and estradiol was 45.43 卤5.21)pmol / L, triglyceride was 1.23 卤0.24) and triacylglycerol was 1.72 卤0.20)mmol / L ~ (-1), total cholesterol was 4.94 卤0.66) and 5.82 卤0.58)mmol / L ~ (-1), respectively, respectively, with low density lipoprotein (LDL-C) of 1.23 卤0.24) and triacylglycerol (1.23 卤0.24), total cholesterol of 1.72 卤0.20)mmol / L ~ (-1), total cholesterol of 4.94 卤0.66) and low density lipoprotein of 5.82 卤0.58)mmol / L ~ (-1) ~ (-1), respectively, in the test group and the control group, they were 11.70 卤1.13) and 28.36 卤4.48 U / L ~ (-1), respectively. The alcohol levels were 2.64 卤0.36 and 3.25 卤0.31)mmol / L, respectively, and the high density lipoprotein cholesterol were 1.66 卤0.21) and 1.38 卤0.13)mmol / L ~ (-1) respectively, the differences were statistically significant (all P 0.05). There were 2 insomnia and 2 headache in the trial group. There were no adverse drug reactions in the control group. The incidence of total adverse drug reactions in the experimental group and control group were 9.30% and 0, respectively, with no significant difference (P 0.05). Conclusion the clinical efficacy of Diflexigestone tablets in the treatment of women with menopausal syndrome is definite. It can effectively regulate blood lipid and sex hormone levels, and does not increase the incidence of adverse drug reactions.
【作者单位】：宁波鄞州人民医院妇产科;
【基金】：浙江省医药卫生计划基金资助项目(2011RCB010)
【分类号】：R711.75

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