糖尿病视网膜病变患者血清血管内皮生长因子及其受体2和血小板反应性蛋白-1的表达

发布时间：2018-03-23 04:40

本文选题：糖尿病　切入点：视网膜病变　出处：《中国老年学杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的检测糖尿病视网膜病变患者血清中血管内皮生长因子(VEGF)、VEGF受体(VEGFR)-2和血小板反应性蛋白(TSP)-1的水平,分析其临床意义。方法 48例2型糖尿病(T2DM)伴有视网膜病变患者作为观察组,T2DM不伴有视网膜病变患者24例作为对照组,15例体检证实为健康成人血清标本作为正常对照组,应用酶联免疫吸附实验检测3组血清VEGF、VEGFR-2和TSP-1的表达。结果 3组血清中VEGF、VEGFR-2和TSP-1的表达差异有统计学意义(P0.05)。观察组中VEGF、VEGFR-2和TSP-1的表达与是否为增殖期密切相关。观察组中VEGF和VEGFR-2正相关,其他指标间无相关性。结论血清中VEGF和VEGFR-2高表达、TSP-1低表达与糖尿病伴有视网膜病变患者病变的形成和进展有关。VEGF、VEGFR-2和TSP-1的检测可能对糖尿病视网膜病变的早期诊断和治疗有一定帮助。
[Abstract]:Objective to detect the levels of vascular endothelial growth factor (VEGF) VEGF receptor VEGFR- 2 and platelet reactive protein (TSP-1) in the serum of patients with diabetic retinopathy. Methods 48 patients with type 2 diabetes mellitus (T2DM) with retinopathy were treated as control group (n = 24) without retinopathy, and 15 healthy adult serum samples were used as normal control group. The expression of VEGFR-2 and TSP-1 in serum of three groups was detected by enzyme-linked immunosorbent assay (Elisa). Results there was a significant difference in the expression of VEGFR-2 and TSP-1 between the three groups. The expression of VEGFFR-2 and TSP-1 in the observation group was closely related to whether the expression of VEGFR-2 and VEGFR-2 was in the proliferative phase. There was a positive correlation between VEGF and VEGFR-2 in the group, Conclusion the high expression of VEGF and VEGFR-2 in serum and the low expression of TSP-1 may be related to the formation and progression of diabetic retinopathy. The detection of VEGFV EGFR-2 and TSP-1 may be an early diagnosis of diabetic retinopathy. And treatment is helpful to some extent.
【作者单位】：牡丹江医学院附属红旗医院内分泌科;牡丹江医学院附属红旗医院眼科;
【基金】：牡丹江市科学技术计划项目(No.Z2015s0036)
【分类号】：R587.2;R774.1

【相似文献】