老年2型糖尿病合并甲状腺功能异常的危险因素

发布时间：2018-03-23 05:39

本文选题：型糖尿病　切入点：甲状腺功能异常　出处：《中国老年学杂志》2016年13期 　论文类型：期刊论文

【摘要】：目的探讨老年2型糖尿病(T2DM)患者合并甲状腺功能异常的危险因素。方法回顾性分析柳州市人民医院内分泌科2014年6月至2015年6月250例老年T2DM患者,观察T2DM患者甲状腺功能异常的患病情况和分布特点,T2DM合并甲状腺功能异常患者为研究组102例,不合并甲状腺功能异常为对照组148例,采用Logistic回归分析方法,对T2DM患者合并甲状腺功能异常的相关危险因素进行探讨。结果 102例T2DM合并甲状腺功能异常患者中甲状腺功能减低74例(72.55%),女54例(52.94%)、男20例(19.61%),甲状腺功能亢进28例(27.45%),女17例(16.67%),男11例(10.78%),女性甲状腺功能异常的患病率明显高于男性(P0.05)。与对照组相比较,研究组的体重指数(BMI)、甘油三酯(TG)、空腹C肽(CP)、糖化血红蛋白(Hb A1c),低密度脂蛋白胆固醇(LDL-C)均增高(P0.05),游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)及促甲状腺素(TSH)均有明显变化(P0.05)。Logistic回归分析显示:病程、Hb A1c是T2DM患者合并甲状腺功能异常的影响因素(P0.05)。结论 T2DM患者合并甲状腺功能异常较常见,应筛查和随访糖尿病患者的甲状腺功能,对指导糖尿病治疗有重要意义。
[Abstract]:Objective to investigate the risk factors of thyroid dysfunction in elderly patients with type 2 diabetes mellitus (T2DM). Methods 250 elderly patients with T2DM from June 2014 to June 2015 were retrospectively analyzed in Department of Endocrinology, Liuzhou people's Hospital. To observe the prevalence and distribution of thyroid dysfunction in patients with T2DM, 102 patients with T2DM complicated with thyroid dysfunction and 148 patients without thyroid dysfunction were studied. Logistic regression analysis was used. Results among 102 cases of T2DM with thyroid dysfunction, 74 cases were hypothyroidism, 54 cases were female, 20 cases were male, and 28 cases were hyperthyroidism. The incidence of thyroid dysfunction in women was significantly higher than that in men (P 0.05). Body mass index (BMI), triglyceride (TGN), fasting C-peptide (CPN), glycosylated hemoglobin (HbA1cN), low density lipoprotein cholesterol (LDL-C), free triiodothyronine (FT3), free thyroxine FT4 (FT4) and thyrotropin TSHwere significantly increased in the study group. Logistic regression analysis showed that HbA1c was the influencing factor of thyroid dysfunction in patients with T2DM. Conclusion T2DM patients with thyroid dysfunction are more common. The thyroid function of diabetic patients should be screened and followed up, which is of great significance in guiding the treatment of diabetes.
【作者单位】：柳州市人民医院内分泌科;
【分类号】：R587.1;R581

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