老年男性代谢综合征患者血清CTRP1水平及其与血清脂联素水平的关系

发布时间：2018-03-23 11:42

本文选题：代谢综合征　切入点：高血压　出处：《上海交通大学学报(医学版)》2017年02期

【摘要】：目的·观察老年男性代谢综合征(MS)患者血清补体C1q肿瘤坏死因子相关蛋白1(CTRP1)水平的变化,并探讨其与血清脂联素(APN)水平的关系。方法·对279例60~90岁男性研究对象的临床资料进行回顾性分析,所有对象均经酶标记免疫吸附试验(ELISA)测定血清CTRP1和APN水平。其中MS患者105例(MS组),MS合并高血压患者(HMS组)90例,非MS患者(对照组)84例;记录一般资料,包括身高、体质量、收缩压、舒张压及空腹血糖、空腹胰岛素和血清三酰甘油(TAG),计算体质量指数(BMI)和稳态模型胰岛素抵抗指数(HOMA-IR)。结果·与对照组比较,MS组和HMS组患者血清CTRP1水平均升高,HMS组升高更明显;HMS组和MS组患者血清APN水平明显降低。血清CTRP1水平与APN水平呈负相关。血清CTRP1水平与血糖、BMI、收缩压、TAG和HOMA-IR呈正相关。结论·老年男性MS患者血清CTRP1水平升高,APN水平降低;MS合并高血压患者的血清CTRP1水平更高。血清CTRP1水平与多项动脉粥样硬化因素有关。
[Abstract]:Objective to observe the changes of serum complement C1q tumor necrosis factor-related protein 1 (CTRP1) levels in elderly male patients with metabolic syndrome (MS). The relationship between APN and serum adiponectin levels was studied. Methods the clinical data of 279 male subjects aged 60 to 90 years were analyzed retrospectively. The serum levels of CTRP1 and APN were measured by Elisa in all subjects. Among them, 90 cases were in MS group, 90 cases in MS group and 84 cases in non-MS group (control group, 84 cases), and the general data, including height and body weight, were recorded. Systolic blood pressure, diastolic blood pressure and fasting blood glucose, Fasting insulin and serum triacylglycerol tago, body mass index (BMI) and homeostasis model insulin resistance index (HOMA-IRN) were calculated. Results compared with the control group, the serum CTRP1 levels of patients in MS and HMS groups were higher than those in HMS group and MS group. Serum APN level was significantly decreased, serum CTRP1 level was negatively correlated with APN level, and serum CTRP1 level was positively correlated with blood glucose, systolic blood pressure, tag and HOMA-IR. Conclusion Serum CTRP1 level in elderly male patients with MS is higher than that in controls. Serum CTRP1 level was higher in patients with hypertension, and serum CTRP1 level was associated with multiple atherosclerosis factors.
【作者单位】：上海交通大学医学院附属瑞金医院老年病科;
【基金】：上海交通大学医工(理)交叉研究基金(YG2014MS55)~~
【分类号】：R589

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