成人斯蒂尔病临床特征及治疗研究

发布时间：2018-03-25 05:20

本文选题：成人斯蒂尔病　切入点：临床特点　出处：《重庆医科大学》2015年硕士论文

【摘要】：目的探讨成人斯蒂尔病(AOSD)的临床特点,分析、总结治疗经验。方法对重庆医科大学附属第一医院2006年11月～2014年1月间诊治的73例成人斯蒂尔病患者进行回顾分析并随访,收集临床资料,进行临床分析。结果73例患者发热、皮疹、关节痛发生率分别为100%、89%、61.6%,淋巴结肿大45例,脾大25例,白细胞升高62例,铁蛋白升高70例。73例患者中单独使用非甾体类抗炎药有效的有3例。其余70例使用糖皮质激素,其中18例联合改变病情的抗风湿药治疗。随访中4例失访,复发15例,余下54例未再复发。结论成人斯蒂尔病(AOSD)是慢性自限性疾病,以发热、皮疹、关节痛为主要表现。血清学以白细胞及血清铁蛋白升高为主,其中铁蛋白升高对于诊断具有高度特异性。确诊后可予以非甾体抗炎药及糖皮质激素,若症状无缓解可加用改变病情的抗风湿药物。
[Abstract]:Objective to investigate the clinical features, analysis and treatment experience of adult Steele's disease (AOSD). Methods 73 adult patients with Steele's disease were retrospectively analyzed and followed up from November 2006 to January 2014 in the first affiliated Hospital of Chongqing Medical University. Results the incidences of fever, rash and joint pain in 73 patients were 100 and 89, respectively. There were 45 cases of lymphadenomegaly, 25 cases of splenomegaly and 62 cases of leukocytosis. Three of 70 patients with elevated ferritin were treated with non-steroidal anti-inflammatory drugs alone. The remaining 70 patients were treated with glucocorticoid, of which 18 were treated with antirheumatic drugs to change their condition. Conclusion AOSD is a chronic self-limited disease with fever, rash and joint pain as the main manifestations. Serology is mainly characterized by increased leucocyte and serum ferritin. The elevation of ferritin is highly specific for diagnosis. NSAIDs and glucocorticoids can be given after diagnosis. If symptoms are not alleviated, anti-rheumatism drugs can be used to change the condition of the disease.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R593.2

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