γ-谷氨酰转肽酶水平与代谢综合征及其组分间关系

发布时间：2018-03-25 18:52

本文选题：γ-谷氨酰转肽酶(GGT)　切入点：代谢综合征(MS)　出处：《中国公共卫生》2017年08期

【摘要】：目的了解γ-谷氨酰转肽酶(GGT)水平与代谢综合征(MS)及其组分之间的关系,为临床工作中利用GGT水平诊断MS提供科学依据。方法采用立意抽样方法收集北京市小汤山医院2012年1—12月28 057名体检人群的体检资料,采用Pearson相关分析GGT水平与MS相关组分之间的相关性,将按照GGT水平四分位数法分为13.0、13.0~19.0、19.1~31.0、31.0 U/L 4组进行二分类logistic回归模型分析不同GGT水平与MS发生风险之间的关系,应用受试者工作特征曲线(ROC)分析GGT水平诊断MS的最佳临界值。结果 MS组人群的GGT水平为(40.96±4.17)U/L,高于非MS组人群的(24.10±2.49)U/L,差异有统计学意义(t=-27.048,P0.01);两变量Pearson相关分析以及调整了性别、年龄和M S其他组分后的偏相关分析结果显示,GGT水平与体质指数、收缩压、舒张压、空腹血糖、甘油三酯MS组分均呈正相关(均P0.01),与高密度脂蛋白胆固醇MS组分均呈负相关(均P0.01);在控制了性别和年龄等混杂因素后,二分类logistic回归分析结果显示,GGT 13.0~19.0 U/L组、19.1~31.0 U/L组、31.0 U/L组人群M S发病风险分别为GGT13.0 U/L组人群的1.247倍(OR=1.247,95%CI=1.133~1.374)、2.375倍(OR=2.375,95%CI=2.166~2.605)、4.729倍(OR=4.729,95%CI=4.323~5.173);ROC曲线结果显示,男性和女性GGT水平诊断M S的ROC曲线下面积分别为0.687和0.747,诊断MS的截断值分别为24.5和13.5 U/L,灵敏度分别为0.715和0.806,特异度分别为0.563和0.580。结论 GGT水平与MS及其组分之间存在相关关系,GGT水平的升高能够增加MS的发生风险,可作为MS发生的标志物。
[Abstract]:Objective to investigate the relationship between the level of 纬 -glutamyl transpeptidase (GGT) and metabolic syndrome (MS) and its components. To provide the scientific basis for the diagnosis of MS by using GGT level in clinical work. Methods the physical examination data of 28 057 people in Beijing Xiaotangshan Hospital from January to December 2012 were collected by using the idea sampling method. Pearson correlation analysis was used to analyze the correlation between GGT level and MS components. According to the GGT level quartile method, a two-class logistic regression model was used to analyze the relationship between different GGT levels and the risk of MS. Results the GGT level of MS group was 40.96 卤4.17U / L, which was higher than that of non-MS group (24.10 卤2.49U / L), the difference was statistically significant (P 0.01). The results of partial correlation analysis between age and other components of MS showed that GGT level and body mass index, systolic blood pressure, diastolic blood pressure, fasting blood glucose, There was a positive correlation between MS components of triglycerides (all P 0.01) and negative correlation with MS components of high density lipoprotein cholesterol (all P 0.01). The results of two-classification logistic regression analysis showed that the risk of M S in GGT 13.0 / 19.0 UL group 19.1and 31.0 UL group was 1.247 times as high as that in GGT13.0 UP / L group, respectively. The results showed that the OR2.37595CII 2.1662.60595% OR2.37595% OR4.72995CIQ 4.3235.173OC curve showed that the risk of M S in the GGT 13.0U / L group was 1.247 times higher than that in the GGT13.0 UL group. The area under the ROC curve was 0.687 and 0.747 for male and female GGT for MS diagnosis, the truncation value for MS was 24.5 and 13.5 U / L, the sensitivity was 0.715 and 0.806, the specificity was 0.563 and 0.580 respectively. Conclusion the GGT level is higher than MS and its components. The increase of GGT level could increase the risk of MS. It can be used as a marker of the occurrence of MS.
【作者单位】：首都医科大学公共卫生学院;糖尿病防治研究北京市重点实验室;
【基金】：国家自然科学基金(81373099;81502886;81530087) 北京市优秀人才青年骨干个人项目(2014000020124G150) 糖尿病防治研究北京市重点实验室开放性课题(2015TNBF04)
【分类号】：R589

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