益生菌制剂对老年血脂异常患者肠道微生态的临床研究

发布时间：2018-03-26 00:11

本文选题：血脂异常　切入点：老年人　出处：《浙江大学》2017年硕士论文

【摘要】：第一部分:老年血脂异常患者肠道微生态的研究[目的]探讨老年血脂异常患者与健康老年人的肠道微生态差异。[方法]选取老年健康人79例,老年血脂异常者73例,收集一般信息及血脂指标,并观察两组间肠道菌群的组成差异。[结果]与健康老年人相比,老年血脂异常组肠道普拉梭菌、肠球菌、乳酸菌、双歧杆菌、直肠真杆菌显著下降,肠杆菌明显增多,并具有统计学意义,而普氏菌和链球菌无明显变化。[结论]老年血脂异常患者存在肠道微生态紊乱,主要表现为有益菌减少,有害菌增多。第二部分:益生菌制剂对老年血脂异常患者临床疗效观察[目的]观察益生菌制剂对老年血脂异常患者的临床疗效。[方法]选取老年血脂异常患者73例,服药组28例,不服药组45例,服药组给予益生菌制剂双歧杆菌三联活菌胶囊,分别于服药前与服药1年后观察两组间肠道菌群的差异,同时监测血脂变化。[结果]益生菌制剂治疗后,服药组中普拉梭菌、肠球菌、乳酸菌、双歧杆菌、直肠真杆菌上升,而肠杆菌下降;同时低密度脂蛋白、甘油三酯、总胆固醇下降,而高密度脂蛋白上升,均存在统计学差异。[结论](1)益生菌制剂能够调节老年血脂异常者肠道微生态系统;(2)益生菌制剂能够改善血脂水平。
[Abstract]:Part one: the study of intestinal microecology in elderly patients with dyslipidemia [objective] to explore the difference of intestinal microecology between elderly patients with dyslipidemia and healthy elderly. [methods] Seventy-nine healthy elderly and 73 elderly dyslipidemia were selected. To collect general information and blood lipid index, and observe the difference of intestinal microflora composition between the two groups. [results] compared with the healthy elderly, the intestinal clostridium, enterococcus, lactic acid bacteria, bifidobacterium and eubacter rectum in the elderly patients with dyslipidemia decreased significantly. Enterobacter spp. Was significantly increased and had statistical significance, but there were no significant changes in Pueraria and Streptococcus. [conclusion] there is intestinal microecological disorder in elderly patients with dyslipidemia, which is mainly manifested by the decrease of beneficial bacteria. The second part: clinical curative effect of probiotics on elderly patients with dyslipidemia [objective] to observe the clinical effect of probiotics on elderly patients with dyslipidemia. [methods] 73 cases of senile dyslipidemia were selected. There were 28 cases in the medication group and 45 cases in the control group. The probiotics preparation bifidobacterium triple living bacteria capsule was given to observe the difference of intestinal flora between the two groups before and after taking the medicine for one year. [results] after treatment with probiotics, Clostridium praziae, Enterococcus, Lactobacillus, Bifidobacterium, eubacter rectum increased, while Enterobacter decreased, while low density lipoprotein, triglyceride, low density lipoprotein, triglyceride, low density lipoprotein (LDL), triglyceride, [conclusion] probiotics can regulate the intestinal microecosystem in elderly patients with dyslipidemia. (2) probiotics can improve the level of blood lipids.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R589.2

【相似文献】