451例真实世界HIV感染患者临床用药规律探析

发布时间：2018-03-26 00:12

  本文选题：真实世界　切入点：人类免疫缺陷病毒　出处：《中国中西医结合杂志》2017年04期

【摘要】：目的分析真实世界人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染患者临床特征及用药规律。方法基于医院信息系统(hospital information system,HIS)真实世界数据,提取2006年1月—2011年12月全国17家三甲医院HIV感染者病历资料,包括患者一般信息、疾病特征及入院期间中西药临床应用情况。结果共收集451例HIV感染者资料,有年龄记录者261例,平均36岁,其中以18~65岁居多[90.4%(236/261)];男女比例为2.8∶1;HIV患者最常入住的科室为传染病科[66.96%(302/451)],其次为呼吸科[8.2%(37/451)]。患者入院方式以门诊为主[79.6%(359/451)],其中以急诊方式入院占20.18%(91/451)。患者多因感染性疾病住院,其中以结核病最多(8.29%),其次为细菌性肺炎(6.44%)。349例有完整用药记录,共使用西药399种,中成药80种。抗微生物药使用频率最高(11.86%),以复方磺胺甲VA唑最多(2.81%)。80种中成药以清热解毒剂最常用(19.27%),其次为解表剂(10.30%)、补益剂(8.97%)、祛痰剂(7.31%)。抗微生物药联合清热解毒剂是最常见的中西药组合。451例HIV感染者经中西药治疗,病情稳定,好转率达51.2%。结论 HIV感染患者中使用频率最高西药是抗微生物类药,使用频率最高中成药为清热类药物。抗微生物药与清热解毒类中成药联合应用在临床上也较为常见。
[Abstract]:Objective to analyze the clinical characteristics and drug use patterns of patients infected with human immunodeficiency virus (immunodeficiency) virus in real world. Methods based on the real world data of hospital information system, From January 2006 to December 2011, the medical records of HIV infected patients in 17 third-class hospitals in China were collected, including general information of patients, disease characteristics and clinical application of Chinese and western medicine during admission. Results 451 cases of HIV infected patients were collected. There were 261 cases with an average of 36 years of age. Most of them were 180-65 years old [90.4 / 236 / 261]; the most common department for HIV patients with HIV was 2.88: 1; the department of infectious diseases [66.96 / 302451], followed by the respiratory department [8.2+ 37 / 451]. The mode of admission of patients was mainly outpatient [79.663 / 359451], of which 20.1891% were admitted to the emergency department. Most of the patients were hospitalized because of infectious diseases. Among them, most of them were tuberculosis (8.29%), followed by bacterial pneumonia (6.4444). 349 cases had complete drug records, totally 399 kinds of western medicine were used. There are 80 kinds of Chinese patent medicine. The antimicrobial drug is the most frequently used, and the compound sulfamethazol is the most common one, and the most common one is the antipyretic and detoxifying agent, followed by the antipyretic agent (10.30), the tonifying agent (8.97), the expectorant (7.31). The antimicrobial agent combined with the antipyretic detoxification agent is the most commonly used. Is the most common combination of Chinese and western medicine. 451 cases of HIV infected by Chinese and western medicine treatment, Conclusion the antimicrobial drugs are the most frequently used in patients with HIV infection. The antimicrobial and antipyretic drugs combined with antipyretic and detoxifying drugs are also common in clinic.
【作者单位】： 中国中医科学院中医临床基础医学研究所;北京大学口腔医学院口腔黏膜科;中国人民大学统计学院;
【基金】：国家科技重大专项项目(No.2009ZX09502-030)
【分类号】：R512.91
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本文编号：1665478