五苓散辅助罗格列酮治疗糖尿病肾病的临床疗效观察

发布时间：2018-03-29 15:02

本文选题：五苓散　切入点：罗格列酮　出处：《中药药理与临床》2017年04期

【摘要】：目的:研究五苓散辅助罗格列酮治疗糖尿病肾病的临床疗效。方法:选取我院2012年2月至2014年8月68例糖尿病肾病患者为研究对象,将患者随机分为观察组和对照组,每组34例,观察组采用五苓散辅助罗格列酮,对照组采用单纯西药罗格列酮,比较两组的临床疗效,血糖、血脂指标,尿蛋白、肾功能指标以及不良反应。结果:观察组的治疗总有效率为94.1%,显著高于对照组的76.5%,观察组治疗后的空腹血糖、餐后2小时血糖、三酰甘油酯、24h尿微量白蛋白排泄率、血肌酐、血尿素氮分别为(5.48±2.66)mmol/L、(8.16±2.37)mmol/L、(2.04±0.85)mmol/L、(39.52±11.16)μg/min、(77.26±12.31)μmol/L、(7.16±2.57)mmol/L,显著低于对照组的(7.35±1.64)mmol/L、(10.42±3.41)mmol/L、(2.86±1.12)mmol/L、(45.35±11.52)μg/min、(86.48±12.09)μmol/L、(8.72±2.61)mmol/L。观察组的不良反应率为17.6%略高于对照组的14.7%,但差异不显著。结论:五苓散可辅助治疗糖尿病肾病,控制患者的血糖、血脂水平,改善患者肾功能。
[Abstract]:Objective: to study the clinical effect of Wuling Powder assisted rosiglitazone in the treatment of diabetic nephropathy. Methods: 68 patients with diabetic nephropathy from February 2012 to August 2014 in our hospital were randomly divided into observation group and control group. 34 cases in each group were treated with Wuling Powder plus rosiglitazone and the control group with rosiglitazone. The clinical efficacy, blood glucose, blood lipid index, urine protein were compared between the two groups. Results: the total effective rate of treatment in the observation group was 94.1, which was significantly higher than that in the control group. The fasting blood glucose, 2 hour postprandial blood glucose, 24 h urinary microalbumin excretion rate and serum creatinine were observed in the observation group. Blood urea nitrogen was 5.48 卤2.66 mmol / L, respectively, 8.16 卤2.37 mmol / L, 2.04 卤0.85 mmol-L / L, 39.52 卤11.16) 渭 g / mol / L, respectively, 77.26 卤12.31 渭 mol / L, 7.16 卤2.57 mmol / L, respectively, which was significantly lower than that of the control group (7.35 卤1.64 mmol-L / L = 10.42 卤3.41 mmol / L = 2.86 卤1.12 mmol / L) 渭 g / min / L = 86.48 卤12.09 渭 mol / L respectively. The adverse reaction rate of the observed group was 17.72 卤2.61 渭 mol / L / L, but the difference was not significant. Improve the renal function of patients.
【作者单位】：四川省医学科学院.四川省人民医院;成都市中西医结合医院;
【分类号】：R587.2;R692.9

【相似文献】