转化生长因子-β1及其介导的信号通路在百草枯致肺上皮间质转化中的作用

发布时间：2018-03-31 10:19

本文选题：百草枯　切入点：肺纤维化　出处：《环境与职业医学》2017年08期

【摘要】：近年来,除草剂在农业生产中广泛使用,中毒事件时有发生,其中以百草枯中毒多见,死亡率较高。百草枯中毒的主要靶器官是肺脏,其病理改变主要为早期的肺泡炎、肺水肿及晚期的肺纤维化。百草枯中毒致肺纤维化的机制复杂,新近研究发现多种细胞因子及其介导的信号通路是百草枯致肺纤维化形成过程中的关键环节。本文对转化生长因子-β1(TGF-β1)及其介导的主要细胞信号通路(Smads、MAPK、Wnt)在百草枯致肺上皮间质转化中的作用进行综述。
[Abstract]:In recent years, herbicides are widely used in agricultural production, and poisoning events occur frequently, among which paraquat poisoning is more common and mortality is higher. The main target organ of paraquat poisoning is lung, and its pathological changes are mainly early alveolitis. Pulmonary edema and late pulmonary fibrosis. The mechanism of pulmonary fibrosis caused by paraquat poisoning is complicated. Recent studies have found that many cytokines and their mediated signaling pathways are the key link in the process of pulmonary fibrosis induced by paraquat. In this paper, we studied the expression of transforming growth factor-尾 1 (TGF- 尾 1) and its main cell signaling pathway, SmadsMAPKwnt, in paraquat induced by paraquat. The role of interstitial transformation in pulmonary epithelium was reviewed.
【作者单位】：济南大学山东省医学科学院医学与生命科学学院;山东省医学科学院山东省职业卫生与职业病防治研究院;山东大学附属省立医院中毒与职业病科;
【基金】：山东省中医药科技发展计划(编号:2015-328) 山东省自然科学基金(编号:ZR2015YL046)
【分类号】：R595.4

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