基于MRI图像的眼眶脂肪体积定量测定方法

发布时间：2018-03-31 10:50

本文选题：眼眶脂肪体积　切入点：甲状腺相关性眼病　出处：《南方医科大学学报》2017年09期

【摘要】：目的建立一种新型基于MRI图像简单、快速、定量测量眼眶脂肪体积的方法。方法本文采集甲状腺相关性眼病患者眼眶和标准脂肪模具的自旋回波序列T1WI成像的MRI图像,通过计算单层脂肪截面积,利用体积累加的方法进行体积定量测量,并对操作计时,同时检验测量方法的精确度、信度和可重复性,以及测量者间的一致性。结果本文所建立的新方法可准确测量出眼眶脂肪体积(平均差百分比绝对值均1%),耗时短,可重复性高(CV均1%),可信度优(ICC=0.996,95%CI:0.985~0.999),一致性高(Bland-Altman差值法分析95%一致性界限:-0.54~0.90)。结论这是一种快速简单测量眼眶脂肪体积的新方法,具有耗时短、精确度高、重复性好、一致性高、可信度优、学习成本低等优势,极具临床推广价值。
[Abstract]:Objective to establish a new method for quantitative measurement of orbital fat volume based on MRI images. Methods the MRI images of orbit and standard fat mould of patients with thyroid associated ophthalmopathy were collected by spin echo sequence T1WI imaging. By calculating the section area of single layer fat, using the method of volume accumulation to measure the volume quantitatively, and timing the operation, the accuracy, reliability and repeatability of the measurement method are also tested. Results the new method established in this paper can accurately measure the volume of orbital fat. The reproducibility and reliability of ICC0.99695 CI: 0.9850.999and Bland-Altman difference analysis 95% -0.540.900.Conclusion this new method is a fast and simple method for measuring orbital fat volume, which has the advantages of short time consuming, high accuracy, good repeatability and high consistency. Good credibility, low learning cost and other advantages, very valuable for clinical promotion.
【作者单位】：南方医科大学第三附属医院内分泌代谢科;
【基金】：广东省高水平大学建设项目临床研究基金(LC2016PY046) 广东省基础研究及应用研究重大项目(2016KZDXM019)
【分类号】：R581

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