升降散加减方联合厄贝沙坦对早期糖尿病肾病的疗效分析

发布时间：2018-03-31 12:42

本文选题：升降散　切入点：早期糖尿病肾病　出处：《华北理工大学》2017年硕士论文

【摘要】：目的观察升降散加减方联合厄贝沙坦对早期糖尿病肾病患者的瘦素、尿微量白蛋白、胱抑素C、β2微球蛋白、血脂、同型半胱氨酸、超敏C-反应蛋白等指标的影响,从而证明联合治疗通过对早期糖尿病肾病患者血脂水平、瘦素等的调节,对肾功能有一定的改善,为中西医联合治疗早期糖尿病肾病提供数据及理论支持。方法将符合标准的2型糖尿病肾病患者按照随机、开放的原则平均分成两组,每组各31人。其中对照组予饮食干预、健康教育、体育锻炼,胰岛素控制血糖等常规治疗,并予厄贝沙坦150mg,每天1次。治疗组在此基础上予升降散加减方,每日一剂,早晚各一次,每次150m L。待疗程8周后,观察并比较治疗前后两组患者的临床症状体征及各项实验室指标的变化。结果经治疗后,两组观察对象总有效率分别为:治疗组90.3%,对照组74.2%,与对照组相比治疗组总有效率明显较高(P0.05);治疗后,治疗组Cys C、UAER、TG、HDL、Leptin与对照组相比差异显著(P0.05),差值具有统计学意义(P0.05)。结论升降散加减方与厄贝沙坦联合使用对早期糖尿病肾病患者的高血脂状态有所改善,并可调节瘦素水平,还可减少尿蛋白的排泄,进而明显改善肾功能,且效果优于单纯厄贝沙坦的使用,值得临床进一步研究及应用。
[Abstract]:Objective to observe the effects of Shengshang decoction and irbesartan on leptin, urinary microalbumin, cystatin C, 尾 2 microglobulin, blood lipid, homocysteine and hypersensitive C-reactive protein in patients with early diabetic nephropathy. It is proved that combined therapy can improve renal function by regulating blood lipid level and leptin levels in early diabetic nephropathy patients. Methods the patients with type 2 diabetic nephropathy were divided into two groups according to the principle of randomness and openness, 31 people in each group. The control group was treated with diet intervention. Health education, physical exercise, insulin control of blood glucose and other routine treatment, and irbesartan 150 mg, once a day. Observe and compare the changes of clinical symptoms and signs and laboratory indexes before and after treatment. The total effective rates of the two groups were 90.3 in the treatment group and 74.2in the control group. The total effective rate of the treatment group was significantly higher than that of the control group (P 0.05). The difference between the treatment group and the control group was significant (P 0.05), and the difference was statistically significant (P 0.05). Conclusion the combination of Shengsheng Powder and Irbesartan can improve the hyperlipidemia of the patients with early diabetic nephropathy and regulate the level of leptin. It can also reduce urinary protein excretion and improve renal function obviously, and the effect is better than that of irbesartan alone, which is worthy of further clinical study and application.
【学位授予单位】：华北理工大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R587.2;R692.9

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