积雪苷片联合热敷药外敷对局限性硬皮病患者的疗效观察

发布时间：2018-04-03 00:11

  本文选题：积雪苷片　切入点：热敷药外敷　出处：《中国皮肤性病学杂志》2017年08期

【摘要】：目的探讨积雪苷片联合热敷药外敷对局限性硬皮病患者疗效观察及皮肤硬度和关节功能的影响。方法选取我院诊治的局限性硬皮病患者96例,按照随机数字表法分组,对照组32例予以积雪苷片联合肝素钠软膏外用治疗,空白对照组32例给予积雪苷片联合热敷治疗,治疗组32例予以积雪苷片联合热敷药外敷治疗,由专业人员记录临床症状评分、血清细胞因子水平,采用免疫组织化学SP法检测皮损VEGF及TGF-β1水平,同时对比临床疗效及并发症。结果对照组有效率75.00%,空白对照组有效率59.38%,均低于治疗组有效率(93.75%),差异有统计学意义(P0.05);与治疗前比较,三组患者治疗后皮肤硬度、关节功能及关节痛评分降低,血清白介素2α受体(sI L-2R)、TNF-α水平降低,治疗后皮损VEGF及TGF-β1水平降低,差异有统计学意义(P0.05);与对照组及空白对照组相比,治疗组皮肤硬度、关节功能及关节痛评分较低,血清sI L-2R,TNF-α水平较低,治疗后皮损VEGF及TGF-β1表达较低,差异有统计学意义(P0.05)。结论积雪苷片联合热敷药外敷可以降低局限性硬皮病患者皮肤硬度积分及关节功能积分,疗效显著。
[Abstract]:Objective to investigate the effect of snow glycoside tablets combined with hot compress on local scleroderma and the effects of skin hardness and joint function.Methods Ninety-six patients with localized scleroderma in our hospital were divided into two groups: the control group (n = 32) was treated with snow glycoside tablet combined with heparin sodium ointment, and the blank control group (n = 32) was treated with snow glycoside tablet combined with hot compress.32 patients in the treatment group were treated with snow glycoside tablets combined with hot compress. The clinical symptom score and serum cytokine levels were recorded by professionals. The levels of VEGF and TGF- 尾 1 in skin lesions were detected by immunohistochemical SP method. The clinical efficacy and complications were compared.Results the effective rate was 75.00 in the control group and 59.38 in the blank control group, which was lower than that in the treatment group and 93.755.The difference was statistically significant (P0.055.Compared with that before treatment, the skin hardness, joint function and joint pain score of the three groups were decreased after treatment.The levels of VEGF and TGF- 尾 1 in skin lesions were significantly lower in the treatment group than those in the control group and the blank control group, and the skin hardness, joint function and joint pain score in the treatment group were lower than those in the control group and the blank control group.The expression of VEGF and TGF- 尾 1 in skin lesions was lower after treatment, and the difference was statistically significant (P 0.05).Conclusion the skin hardness score and joint function score of the patients with localized scleroderma can be reduced by the combination of snow glycoside tablets and hot compress, and the curative effect is remarkable.
【作者单位】： 邢台市人民医院;河北医科大学第四医院;
【基金】：河北省卫生厅科研项目(20150174)
【分类号】：R593.25
，

本文编号：1702739