主题模型在2型糖尿病治疗方案研究中的应用

发布时间：2018-04-03 09:56

本文选题：主题模型　切入点：型糖尿病　出处：《中国药房》2017年23期

【摘要】：目的:探讨主题模型在2型糖尿病治疗方案研究中的应用。方法:回顾性分析我院2012年1月-2016年6月650例2型糖尿病住院患者的临床数据,采用MATLAB R2014a软件对患者的临床诊断、实验室指标和临床用药等数据进行转换、汇总及矩阵合并;应用隐狄利克雷分配模型和作者主题模型提取主题概率值0.1的典型主题,并通过累计概率值0.5的并发症对主题进行描述。结果:共获得62个并发症词汇、16个异常实验室指标组和20个治疗方案。共挖掘出4个典型主题(前几项并发症的累计概率值分别为0.878 6、0.824 7、0.821 5、0.753 6,主题概率值分别为0.336 4、0.277 3、0.203 5、0.117 6),分别以周围神经病变、外周血管病变、脂代谢异常和微细血管病变为主要特征,且异常实验室指标组符合上述特征。分布概率较高的并发症包括糖尿病周围神经病变(0.578 7)、高血压(0.363 1)、动脉硬化(0.278 9)、高脂血症(0.457 8)和糖尿病视网膜病变(0.314 3),主要治疗药物包括门冬胰岛素注射液、胰岛素注射液和甲钴胺分散片等。结论:2型糖尿病并发症群以周围神经病变、外周血管病变、脂代谢异常及微血管病变为主要特征。主题模型可从临床数据中提取出有临床意义的用药规律。
[Abstract]:Objective: to explore the application of thematic model in the treatment of type 2 diabetes.Methods: the clinical data of 650 inpatients with type 2 diabetes mellitus from January 2012 to June 2016 were analyzed retrospectively. The data of clinical diagnosis, laboratory index and clinical medication were converted, summarized and combined with matrix by MATLAB R2014a software.A typical topic with a probability value of 0.1 is extracted by using the implicit Dirichlet assignment model and the author's topic model, and the topic is described by the complications of the cumulative probability value of 0.5.Results: a total of 62 complications vocabulary, 16 abnormal laboratory indicators and 20 treatment protocols were obtained.A total of four typical themes were excavated (the cumulative probability values of the first few complications were 0.878 ~ 0.824 7 ~ 0.821 5 ~ 0.753 6, respectively), and the thematic probability values were 0.336 ~ 4 ~ 0.277 ~ 3 ~ 0.203 ~ 5 ~ 0.117 ~ 6G, respectively, with peripheral neuropathy and peripheral vascular lesion, respectively.Abnormal lipid metabolism and microvascular disease were the main characteristics, and the abnormal laboratory index group accorded with the above characteristics.The complications with higher probability of distribution included diabetic peripheral neuropathy (0.5787), hypertension (0.3631), arteriosclerosis (0.278 9), hyperlipidemia (0.457 8) and diabetic retinopathy (0.314 3). The main therapeutic drugs included insulin aspartic injection.Insulin injection and methylcobalamin dispersible tablets.Conclusion the complications of type 2 diabetes mellitus are mainly characterized by peripheral neuropathy, peripheral vascular disease, abnormal lipid metabolism and microvascular disease.The thematic model can extract the rule of drug use with clinical significance from clinical data.
【作者单位】：中山市博爱医院药学部;中山市博爱医院内分泌科;
【基金】：中山市科学事业费项目(医疗卫生)(No.2015B1180)
【分类号】：R587.1

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