精神分裂症伴代谢综合征患者心脏自主神经功能分析

发布时间：2018-04-03 10:55

  本文选题：精神分裂症　切入点：代谢综合征　出处：《实用医学杂志》2017年19期

【摘要】：目的探讨精神分裂症伴代谢综合征患者心脏自主神经功能状况,并分析其影响因素,以减少患者心源性猝死的发生。方法 168例符合ICD-10精神分裂症诊断标准的患者分为78例精神分裂症伴有代谢综合征组(A组)和90例精神分裂症不伴有代谢综合征组(B组),对其分别进行24 h动态心电图检查,分析其心率变异性(HRV),并与92例正常对照组(C组)进行对比。结果 A组和B组LF、HF、SDNN、SDANN、RMSSD、PNN50值均明显低于C组,差异有统计学意义(P0.05),且B组LF、HF、SDNN、SDANN、RMSSD、PNN50值明显高于A组,差异有统计学意义(P0.05)。排除精神分裂症自身的影响,Logistic回归分析显示HRV值的影响因素为病程(OR=1.864,95%CI 1.110~3.128)、年龄(OR=1.170,95%CI 1.018~2.491)、抗精神病药物种类(OR=2.419,95%CI 0.976~1.835)、腹部肥胖(OR=2.425,95%CI1.347~4.366)、血压值(OR=1.263,95%CI 1.575~3.937)、血糖值(OR=3.376,95%CI 1.359~2.923)、血脂值(OR=2.178,95%CI 1.492~6.756)。结论精神分裂症伴代谢综合征患者存在明显心脏自主神经功能异常,排除精神分裂症自身的影响,其他可能的危险因素是病程、年龄、抗精神病药物种类、腹部肥胖、血压值、血糖值、血脂值。
[Abstract]:Objective to investigate the cardiac autonomic nervous function in schizophrenic patients with metabolic syndrome and analyze its influencing factors in order to reduce the incidence of sudden cardiac death.Methods ICD-10 schizophrenic patients were divided into two groups: 78 patients with schizophrenia with metabolic syndrome (group A) and 90 patients with schizophrenia without metabolic syndrome (group B). The patients were examined by dynamic electrocardiogram for 24 hours.Heart rate variability (HRV) was analyzed and compared with 92 normal controls (group C).Results the values of SDNN50 in group A and group B were significantly lower than those in group C (P 0.05), and the values of SMSSDNN in group B were significantly higher than those in group A (P 0.05).鎺掗櫎绮剧�炲垎瑁傜棁鑷�韬�鐨勫奖鍝�,Logistic鍥炲綊鍒嗘瀽鏄剧ずHRV鍊肩殑褰卞搷鍥犵礌涓虹梾绋，

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