新疆痛风人群SLC2A9基因多态性与认知功能的相关研究

发布时间：2018-04-08 19:11

本文选题：痛风　切入点：SLC2A9基因　出处：《新疆医科大学》2017年硕士论文

【摘要】：目的:目前认为认知功能的损害可能与痛风、肾脏疾病、高血压等临床疾病紧密相关,以上疾病也是痛风患者中常见的多发的并发症。为何要研究此课题,是因为可以解决新疆地域男性病人的一些对普通和特殊认知功能和对某些基因比如与SLC2A9基因SNP的之间的关联。方法:选取新疆汉族地区男性原发性痛风患者和健康体检者分别200名,记录他们的基本资料,比如他们的腰臀比、身高、重量、岁数、健康指数(BMI)、受教育程度、收缩压和舒张压、一般生化资料,使用某些探针如TaqMan测试法,使用临床上常见的特殊心理量表,比如说以下几种量表:WAIS(韦氏成人智力量表)、MMSE(简易精神状态检查量表)、MoCA(蒙特利尔认知评估表)进行检测。因原发性痛风的SLC2A9基因与许多多态性基因相关连比如说rs3733591,rs11722228和rs5568674位点进行多态性基因检测;同时对以上所有基因结果行统计学分析。结果:(1)检测SLC2A9基因中3个SNP位点:其中rs3733591和rs11722228位点基因多态性与痛风易感性相关(P=0.0170,P=0.0005)。(2)病例组与健康体检者的某些指标的统计学数值是否会形成一些显著的差异(P0.05),比较上述两组同时使用MoCA量表,此表的内容包含不同指标的分数,从而可以检测人类的后天的抽象能力、显示语言是否有统计学差异(P0.05)。(3)rs3733591(CC/CT/TT),rs11722228(CC/CT/TT)和rs55686745(CC/CT/TT)各基因型之间尿酸无明显差异(P0.05)。(4)回归分析揭示:SLC2A9基因中rs3733591,rsll722228和rs55686745基因多态性与男性痛风患者认知功能不相关(P0.05)。结论:进行此项研究的人群是新疆汉族男性痛风患者,将他们作为整体部分,从而深入的阐述了痛风人群SLC2A9基因多态性与认知功能关系的研究。
[Abstract]:Objective: it is believed that cognitive impairment may be closely related to gout, kidney disease, hypertension and other clinical diseases. These diseases are also common complications in patients with gout.The reason for this research is that it can solve the relationship between common and special cognitive function of male patients in Xinjiang region and some genes such as SLC2A9 gene SNP.Methods: 200 male patients with primary gout and 200 healthy people in Xinjiang Han nationality were selected to record their basic data, such as waist-to-hip ratio, height, weight, age, health index and educational level.Systolic and diastolic blood pressure, general biochemical data, use of certain probes such as TaqMan test, use of clinical common special psychological scale,For example, the following scales: WAIS (Wechsler Adult Intelligence scale) MMSE (simple Mental State scale) were tested by MoCA (Montreal Cognitive Assessment scale).The SLC2A9 gene of primary gout was associated with many polymorphic genes, such as rs3733591, rs11722228 and rs5568674, and the results of all the above genes were analyzed statistically.Results: 1) three SNP loci in the SLC2A9 gene were detected. Among them, the polymorphism of rs3733591 and rs11722228 loci was associated with the susceptibility to gout.) the statistical values of some indexes in the case group and the healthy persons were significantly different (P 0.05, P < 0.05).Compared with the above two groups, using MoCA scale at the same time,The contents of this table contain scores of different indicators, which can measure human's acquired abstract ability.Conclusion: this study was conducted in Xinjiang Han male patients with gout, taking them as a whole, and then the relationship between SLC2A9 gene polymorphism and cognitive function of gout population was discussed.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R589.7

【参考文献】