乌鲁木齐市、托克逊县维吾尔族居民甲状腺疾病与碘营养状况相关性研究

发布时间：2018-04-08 22:24

本文选题：维吾尔族　切入点：尿碘　出处：《新疆医科大学》2017年硕士论文

【摘要】：目的:研究新疆城乡两地区维吾尔族居民碘营养状况、甲状腺疾病及二者相关因素分析。方法:于2015年8月在新疆托克逊地区(B组)采用随机整群抽样方法抽取1383人,资料完整者1285人,其中成年人共1196人,平均年龄(44.12±15.0)岁,8~10岁的儿童89人。2015年10月在新疆乌鲁木齐市天山区(A组)采用同样的抽样方法抽取2187人,资料完整者1976,其中成年人共1740人,平均年龄(42.24±15.46)岁,8~10岁的儿童共236人。通过问卷调查、食物模型及三日称量记账法对居民日常富碘饮食及每日食盐摄入量调查。同时采集食用盐、饮用水和一次尿样及血标本,分别测定盐碘、水碘和尿碘、促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb),TSH异常者测定FT3、FT4。结果:(1)两地区维吾尔族居民日常膳食中摄入富碘食物均较少,其中农村地区较城市更少(?2=7.715,P=0.005),A组成人尿碘中位数为128.78ug/L,儿童尿碘中位数为244.27ug/L,B组成人尿碘中位数为171.2 ug/L,儿童尿碘中位数为292.17ug/L,两组各年龄段均有不同程度碘缺乏及碘过量。(2)不同文化水平、年龄、性别尿碘分布有所不同。(3)农村碘营养状况较城市良好。(4)甲状腺功能异常者共458人,城市患病率高于农村。(5)两地区logistic回归分析发现性别、年龄、吸烟、碘过量是甲状腺功能异常的危险因素。(6)根据碘营养状况分组,两地区碘过量组亚甲减患病率最高。结论:两地区加碘盐实施达标,但仍有部分居民处于碘缺乏状态,需跟踪随访。针对甲状腺疾病易感人群需进行甲状腺疾病随访,对于可控危险因素应积极避免。
[Abstract]:Objective: to study the iodine nutrition status, thyroid disease and related factors of Uygur population in urban and rural areas of Xinjiang.Methods: in August 2015, 1383 individuals were sampled by random cluster sampling in Group B of Tok Xun region, Xinjiang. The data were complete in 1285 people, including 1196 adults.The daily iodine rich diet and salt intake of residents were investigated by questionnaire, food model and 3-day weighing and accounting method.Salt, drinking water, primary urine samples and blood samples were collected at the same time. Salt iodine, water iodine and urine iodine, thyroid stimulating hormone TSH, thyroid peroxidase antibody TPOAbA, thyroid globulin antibody TgAbn TSH were measured respectively.Results (1) the Uygur residents in the two regions had less iodine rich food in their daily diet.(II) different levels of culture,The distribution of urinary iodine was different in age and sex. (3) the iodine nutritional status in rural area was better than that in urban area. There were 458 people with abnormal thyroid function. The prevalence rate in urban area was higher than that in rural area. Logistic regression analysis showed that sex, age and smoking.Iodine excess is the risk factor of thyroid dysfunction. 6) according to the iodine nutritional status, the prevalence of hypothyroidism was the highest in the iodine excess group.Conclusion: the implementation of iodized salt in the two areas is up to the standard, but some residents are still in iodine deficiency, which should be followed up.Thyroid disease should be followed up for the susceptible population, and controllable risk factors should be avoided.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R581

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