血液胆碱酯酶活性作为生物监测指标应用中的注意事项

发布时间：2018-04-12 10:46

本文选题：血液胆碱酯酶活性 + 生物监测　；参考：《环境与职业医学》2016年10期

【摘要】：在有机磷农药急性暴露和慢性接触的不同方式下,血液胆碱酯酶活性变化呈现不同的规律特征。本文介绍了血液胆碱酯酶活性监测作为替代性生物效应标志,来反映有机磷农药急性暴露对机体胆碱能神经组织毒性作用的意义及其职业病临床应用价值;分析了血液胆碱酯酶活性测定值受暴露时点时程、监测时段、病程时相、酶活性再生阶段等多种时间相关因素的影响;介绍了长期低剂量接触有机磷农药出现胆碱能神经毒性耐受现象时,血液胆碱酯酶活性特征及其衍生出的相关问题,以及在职业健康监护实践应用中的注意事项。
[Abstract]:The changes of blood cholinesterase activity in different ways of acute exposure and chronic exposure to organophosphorus pesticides showed different characteristics.This paper introduces the significance of blood cholinesterase activity monitoring as an alternative biological effect marker to reflect the toxic effect of acute exposure to organophosphorus pesticides on cholinergic nerve tissue and the clinical application value of occupational diseases.The determination value of blood cholinesterase activity was influenced by many time related factors, such as time course of exposure, period of monitoring, phase of course of disease, stage of regeneration of enzyme activity, and so on.In this paper, the characteristics of cholinesterase activity in blood and related problems arising from cholinergic neurotoxicity tolerance of long-term low dose exposure to organophosphorus pesticides were introduced, and the matters needing attention in the practice of occupational health monitoring were also discussed.
【作者单位】：江苏蓝天安全科技有限公司;
【分类号】：R595.4

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