类风湿关节炎表观遗传学研究进展

发布时间：2018-04-12 17:43

  本文选题：类风湿关节炎 + 表观遗传学　； 参考：《中国免疫学杂志》2017年04期

【摘要】：正类风湿关节炎(Rheumatoid arthritis,RA)是一种自身免疫性疾病,以慢性滑膜炎为主要病理改变,临床表现为关节疼痛肿胀、关节损伤和活动受限,最终会导致关节破坏和残疾。以抗瓜氨酸化抗体(Citrullinated peptide antigens,ACPA)是否阳性来划分,RA可以被划分为ACPA+和ACPA-两大类~([1])。ACPA+的RA患者与特定的HLAⅡ类等位基因相关。多项全基因组关联分析(Genome-wide association studies,GWAS)已经确认遗传变异在不同群体
[Abstract]:Rheumatoid arthritis (RA) is an autoimmune disease, with chronic synovitis as the main pathological change. The clinical manifestations are joint pain swelling, joint injury and limited movement, which will eventually lead to joint destruction and disability.According to whether the anti citrullinated peptide antigensus ACPA is positive or not, RA can be divided into two groups: ACPA and ACPA- ([1] .ACPA.) the patients with RA are associated with specific HLA class 鈪，

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