基于对比增强流场的2型糖尿病患者颈动脉窦区壁剪应力分布分析

发布时间：2018-04-15 15:46

本文选题：颈动脉 + 壁面剪应力　；参考：《中国医学影像技术》2017年04期

【摘要】：目的采用对比增强流场(CEFF)技术观察2型糖尿病(T2DM)患者颈动脉窦区壁面剪应力(WSS)的分布规律。方法选取47例T2DM患者和25名健康志愿者(对照组),并根据颈总动脉内中膜厚度(IMT)将T2DM患者分为IMT正常组(n=21)和IMT增厚组(n=26),采用CEFF分析软件,计算颈动脉窦区WSS,绘制相应WSS空间分布图,记录颈内动脉起始段后壁WSS值并进行统计学分析。结果 3组颈动脉窦区均存在两个低WSS区和一个高WSS区:颈总动脉远端至颈内动脉起始段后壁存在大范围低WSS区,颈总动脉远端前壁存在小范围低WSS区,颈内动脉起始段前壁为高WSS区。IMT正常组[(3.39±0.60)dyne/cm~2]和IMT增厚组[(2.58±0.46)dyne/cm~2]患者颈内动脉后壁WSS值均较对照组[(3.74±0.53)dyne/cm~2]显著减低(P均0.05);IMT增厚组较IMT正常组减低(P0.05)。结论 CEFF图像技术可初步定量检测动脉WSS,有望早期、可视化评估颈动脉硬化。
[Abstract]:Objective to observe the distribution of wall shear stress (WSS) in type 2 diabetes mellitus (T2DM) patients by contrast-enhanced flow field (CEF) technique.Methods 47 patients with T2DM and 25 healthy volunteers (control group) were divided into IMT normal group (n = 21) and IMT thickening group (n = 26) according to common carotid artery intima-media thickness (IMT). CEFF analysis software was used.The spatial distribution of WSS was plotted and the WSS value of the posterior wall of the internal carotid artery was recorded and analyzed statistically.Results there were two low WSS regions and one high WSS area in the carotid sinus region in all the three groups: there was a large area of low WSS area from the distal part of the common carotid artery to the posterior wall of the internal carotid artery, and a small area of low WSS area in the anterior wall of the distal common carotid artery.The WSS value of the posterior wall of the internal carotid artery in the patients with the anterior wall of the internal carotid artery at the beginning of the internal carotid artery was significantly lower than that in the control group [3.74 卤0.53)dyne/cm~2] in the normal group [3.39 卤0.60)dyne/cm~2] and in the IMT thickening group [2.58 卤0.46)dyne/cm~2] compared with that in the control group [3.74 卤0.53)dyne/cm~2] (P < 0.05) and the value of P0.05in the thickening group was significantly lower than that in the control group (P < 0.05).Conclusion CEFF image technique can be used to quantitatively detect carotid artery and to evaluate carotid atherosclerosis in early stage.
【作者单位】：同济大学附属东方医院医学超声科;
【基金】：上海市卫生和计划生育委员会科研课题面上项目(201440335) 东方起航计划科研项目青年基金(DFQH-Q16)
【分类号】：R587.1;R445.1

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