急进高原后人外周血红细胞形态变化的研究

发布时间：2018-04-17 23:26

本文选题：高原反应 + 红细胞形态　；参考：《中国输血杂志》2017年08期

【摘要】：目的探讨高原环境下人体外周血红细胞形态与高原反应的关系,为高原反应的预防和治疗提供实验依据。方法设急进高原组:世居海拔约500 m平原地区的受试者25名,分别于其急进高原前后采集外周血血样各5m L/(人)份;久居高原组:受试者14名,居住在海拔约3 600 m地区10年,包括世居高原的藏族人7名、居住高原10-15年的汉族人7名,采集其外周血血样5 m L/(人)份;调查2组的高原反应发生情况,扫描电镜观察2组受试者红细胞形态,统计分析2组受试者不同形态红细胞数量。结果在海拔约3 200及3 600 m高原地区,急进高原组均出现不同程度的高原反应,久居高原组则无高原反应情况发生。正常形态的外周血红细胞数量(个/份):急进高原组急进高原前后分别为471.43±1.35(海拔约500 m)、263.31±6.16(海拔约3 200 m)、256.29±13.03(海拔约3 600m)(P0.01),且畸形红细胞数量明显增加;久居高原组为368.57±11.26,明显高于急进高原组(P0.01),且畸形红细胞数量明显低于急进高原组。久居高原组中藏族和汉族人群的正常形态的外周血红细胞数量相近(P0.05)。结论正常健康成年人急进高原后,外周血红细胞的畸形化改变可能是高原反应发生的机理之一。
[Abstract]:Objective to study the relationship between erythrocyte morphology of human peripheral blood and altitude reaction in high altitude environment, and to provide experimental basis for prevention and treatment of altitude reaction.Methods A total of 25 subjects living at an altitude of about 500 m were divided into two groups: 25 subjects were collected blood samples from peripheral blood before and after they entered the plateau, and 14 subjects lived at altitude of about 3 600 m for 10 years.There were 7 Tibetans who lived on the plateau and 7 Han people who lived on the plateau for 10-15 years. The peripheral blood samples were collected from 7 Tibetans and 7 Han people living on the plateau. The occurrence of plateau reaction in the two groups was investigated, and the erythrocyte morphology of the two groups was observed by scanning electron microscope.The number of erythrocytes of different morphology in two groups were analyzed statistically.Results in the altitude of about 3 200 m and 3 600 m above sea level, there were different degrees of high altitude reaction in the rapid entry plateau group, but there was no high altitude reaction in the long lived plateau group.The number of normal peripheral blood red blood cells was 471.43 卤1.35 (about 263.31 卤6.16) before and after the rapid entry at high altitude (about 256.29 卤13.03 above sea level), and the number of abnormal red blood cells increased significantly.The number of abnormal red blood cells in the long-lived high altitude group was 368.57 卤11.26, which was significantly higher than that in the acute plateau group (P 0.01), and the number of abnormal red blood cells was significantly lower than that in the acute plateau group.The number of normal peripheral blood red blood cells in Tibetan and Han population was similar to that of P0.05 in plateau group for a long time.Conclusion the abnormal changes of peripheral blood red blood cells in healthy adults may be one of the mechanisms of altitude reaction.
【作者单位】：第四军医大学西京医院输血科;空军总医院;
【分类号】：R594.3

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