男性2型糖尿病患者骨密度与C肽水平的关系

发布时间：2018-04-19 12:40

本文选题：型糖尿病 + 骨质疏松　；参考：《中国骨质疏松杂志》2017年01期

【摘要】：目的探讨男性2型糖尿病(type 2 diabetes mellitus,T2DM)患者骨密度(bone mineral density,BMD)的变化与C肽水平关系。方法采用双能X线骨密度仪对143例糖尿病患者和63例非糖尿病者(对照组)进行腰椎L1-4骨密度测量,记录年龄、体重指数(body mass index,BMI)、糖尿病病程。检测糖化血红蛋白(Hb A1c)、骨代谢指标及空腹、餐后2h血糖、C肽。采用C肽改良HOMA公式计算胰岛β细胞功能指数(HOMA-β)和胰岛素抵抗指数(HOMA-CR)。糖尿病患者根据BMD水平分为2组:骨量正常组(DM-A组)和骨量减少/骨质疏松组(DM-B组)。结果糖尿病患者骨密度、空腹及餐后2h C肽均低于对照组(P0.05)。与DM-A组相比,DM-B组HOMA-CR、I型胶原羧基末端肽β特殊序列(βCTX)水平升高(P0.05),I型前胶原羧基末端肽(PICP)水平降低(P0.05)。多元逐步回归结果提示,BMI和空腹C肽是腰椎骨密度的主要影响因素。结论男性2型糖尿病患者骨密度与空腹C肽水平密切相关,C肽水平偏低的男性2型糖尿病患者更容易发生骨密度降低。
[Abstract]:Objective to investigate the relationship between bone mineral density (BMD) and C-peptide level in male patients with type 2 diabetes mellitus (type 2 diabetes mellitusus T2DM).Methods L1-4 bone mineral density of lumbar vertebrae was measured by dual energy X-ray absorptiometry in 143 diabetic patients and 63 non-diabetic subjects (control group). Age, body mass index (BMI) and body mass index (mass) were recorded.The levels of HbA1cX, bone metabolism, fasting and 2 h postprandial blood glucose C peptide were measured.The 尾 cell function index (HOMA- 尾) and insulin resistance index (HOMA-CRA) were calculated by modified C-peptide HOMA formula.Diabetic patients were divided into two groups according to BMD level: normal bone mass group (DM-A group) and osteopenia / osteoporosis group (DM-B group).Results BMD, fasting and 2 h postprandial C peptide were lower in diabetic patients than those in control group (P 0.05).Compared with DM-A group, HOMA-CRN I carboxyl terminal peptide 尾 (尾 CTX) level in DM-B group was increased and the level of P0.05 procollagen carboxyl terminal peptide (PICPX) was decreased in DM-B group.Multiple stepwise regression analysis showed that BMI and fasting C-peptide were the main influencing factors of lumbar bone mineral density.Conclusion the BMD of male type 2 diabetic patients is closely related to the fasting C-peptide level. The male type 2 diabetic patients with low C-peptide level are more likely to develop BMD decrease.
【作者单位】：上海市杨浦区市东医院内分泌科;同济大学附属同济医院内分泌科;
【基金】：上海市杨浦区卫生和计划生育委员会青年科研课题(201306)
【分类号】：R587.1

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