初发甲状腺功能异常患者与血脂和肥胖的相关性

发布时间：2018-04-20 07:28

本文选题：甲状腺功能 + 血脂代谢　；参考：《中国老年学杂志》2016年23期

【摘要】：目的探讨初发甲状腺功能异常患者与血脂变化和肥胖的相关性。方法选取76例初发甲状腺功能减退症患者(甲减组)、45例初发甲状腺功能亢进症患者(甲亢组)和50例健康成人(对照组)。对甲减组患者服用左甲状腺素钠,甲亢组患者服用甲巯咪唑治疗6个月。测定治疗前后体重、身高、体重指数(BMI)、腰围(WC)、腰围/臀围比值(WHR)、血压、肝功以及血清中甲状腺功能〔游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、甲状腺球蛋白抗体(TGAb)、甲状腺过氧化物酶抗体(TPOAb)〕、血脂〔甘油三酯(TC)、总胆固醇(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)〕的水平;并对各组及治疗前后进行比较与相关性分析。结果甲减组患者BMI、WC、WHR、TC、TG、LDL-C、TSH、TGAb、TPOAb水平显著高于对照组(P0.01),FT3、FT4水平显著低于对照组(P0.01);甲亢组患者BMI、WC、WHR、TC、TG、LDL-C、TSH水平显著低于对照组(P0.01),FT3、FT4、TGAb、TPOAb水平显著高于对照组(P0.01);甲状腺功能异常患者治疗前后相比BMI、WC、WHR、TC、TG、LDL-C、TSH、FT3、FT4相比差异显著(P0.01)。甲状腺功能异常患者WC、WHR与TPOAb具有显著相关性(P0.05)。结论甲状腺功能异常患者存在血脂代谢紊乱,甲状腺自身抗体与腹型肥胖存在关联。
[Abstract]:Objective to investigate the relationship between the changes of blood lipid and obesity in patients with primary thyroid dysfunction. Methods 76 patients with primary hypothyroidism (hypothyroidism group, 45 patients with hyperthyroidism group) and 50 healthy adults (control group) were selected. Patients in hypothyroidism group were treated with levathyroxine sodium and hyperthyroidism group were treated with methimazole for 6 months. Weight, height, body mass index (BMI), waist circumference (WCC), waistline / hip ratio (WHR), blood pressure (BP) were measured before and after treatment. Liver function and serum thyroid function (free triiodothyronine FT _ 3H, free thyroxine FT _ 4T _ 4, TSH), thyroglobulin antibody TGAbA, thyroid peroxidase antibody (TPO), The levels of serum lipids (triglyceride, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol) were compared and analyzed before and after treatment. Results the level of TPOAb in the patients with hypothyroidism was significantly higher than that in the control group (P0.01FT3FT4), and the level of BMIWCC-WHTGLDL-CPOAb in hyperthyroidism group was significantly lower than that in the control group (P 0.01). The level of TPOAb in the patients with thyroid dysfunction was significantly higher than that in the control group (P 0.01), and the difference between the patients with thyroid dysfunction and the patients with thyroid dysfunction before and after the treatment was significantly higher than that in the patients with hyperthyroidism. There was a significant correlation between WCU WHR and TPOAb in patients with abnormal thyroid function (P 0.05). Conclusion there is dyslipidemia in patients with abnormal thyroid function, and thyroid autoantibodies are associated with abdominal obesity.
【作者单位】：首都医科大学附属北京世纪坛医院内分泌科;
【分类号】：R581;R589.2

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