血清GM-CSF、TNF-α及IL-17在类风湿关节炎中的表达及相关性

发布时间：2018-04-21 18:46

本文选题：中性粒细胞巨噬细胞集落刺激因子 + 肿瘤坏死因子-α　；参考：《中国老年学杂志》2017年12期

【摘要】：目的探讨血清中性粒细胞巨噬细胞集落刺激因子(GM-CSF)、肿瘤坏死因子(TNF)-α、白细胞介素(IL)-17在类风湿关节炎(RA)患者中的表达水平及各因子的相关性。方法 80例RA患者为病例组(活动期组42例,稳定期组38例),并于同期随机选取50例健康体检者为对照组,采用酶联免疫吸附法(ELISA)测定各组研究对象的血清GM-CSF、TNF-α、IL-17水平,对比各组GM-CSF、TNF-α、IL-17水平并分析其相关性。结果病例组患者的血清GM-CSF、TNF-α、IL-17水平高于对照组(P0.05)。活动期组、稳定期组患者的血清GM-CSF、TNF-α、IL-17水平均高于对照组,且活动期组患者的GM-CSF、TNF-α、IL-17水平高于稳定期组(P0.05)。经Pearson积矩相关分析,病例组患者血清GM-CSF与TNF-α、IL-17呈正相关(r=0.836、0.752,P0.05),血清TNF-α与IL-17呈正相关(r=0.718,P0.05)。结论 GM-CSF、TNF-α及IL-17在RA中呈高表达水平,并且三者通过相互作用参与了RA的发生发展过程。
[Abstract]:Objective to investigate the expression level of serum neutrophil macrophage colony stimulating factor (GM-CSFN), tumor necrosis factor TNF- 伪 and interleukin (IL) -17 in patients with rheumatoid arthritis (RA). Methods 80 RA patients (active group 42 cases, stable group 38 cases) and 50 healthy persons as control group were randomly selected at the same time. The serum levels of GM-CSF- 伪 TNF- 伪 IL-17 were measured by enzyme linked immunosorbent assay (Elisa). The levels of IL-17 in GM-CSF- 伪 TNF- 伪 were compared and their correlation was analyzed. Results the serum level of GM-CSF- 伪 TNF- 伪 IL-17 was higher in the case group than that in the control group (P 0.05). The serum levels of GM-CSF- 伪 TNF- 伪 IL-17 in active group and stable group were higher than those in control group, and the level of GM-CSF- 伪 TNF- 伪 IL-17 in active group was higher than that in stable phase group (P 0.05). The positive correlation between serum GM-CSF and TNF- 伪 IL-17 was found by Pearson moment correlation analysis, and there was a positive correlation between serum TNF- 伪 and TNF- 伪 IL-17, and between serum TNF- 伪 and IL-17. Conclusion GM-CSF- 伪 TNF- 伪 and IL-17 are highly expressed in RA, and they are involved in the genesis and development of RA through interaction.
【作者单位】：泰安市中心医院风湿免疫科;
【分类号】：R593.22

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