2型糖尿病病人大动脉僵硬度相关危险因素研究

发布时间：2018-04-22 16:01

本文选题：型糖尿病 + 颈动脉内中膜厚度　；参考：《首都医科大学学报》2017年05期

【摘要】：目的探讨分析2型糖尿病病人大动脉僵硬度及其相关危险因素。方法选取北京大学首钢医院2013年9月至2016年9月间收治的582例2型糖尿病病人作为观察组研究对象,同时选取来医院进行常规体检的384名正常人群为对照组,对两组研究对象行一般资料收集、颈动脉超声和脉搏波传导速度检查,观察比较两组检查结果。结果观察组病人收缩压、三酰甘油(triglyceride,TG)、体质量指数(body mass index,BMI)、低密度脂蛋白胆固醇(low density lipoprotein-cholesterol,LDL-C)、胰岛素抵抗指数、C反应蛋白(C reactive protein,CRP)、同型半胱氨酸都高于对照组,高密度脂蛋白胆固醇(high density lipoproteincholesterol,HDL-C)低于对照组,两组差异有统计学意义(P0.05)。观察组病人颈动脉内中膜厚度(intima-media thickness,IMT)、颈-股动脉脉搏波传导速度(carotid-femoral pulse wave velocity,CF-PWV)高于对照组(P0.05),其中观察组单侧斑块检出率为47.59%,对照组为14.22%,观察组双侧颈动脉斑块检出率为33.85%,对照组为5.47%,单、双侧观察组均高于对照组,两组差异有统计学意义(P0.05)。对2型糖尿病病人脉搏波传导速度进行Logistic回归分析得知,年龄、收缩压、LDL-C、胰岛素抵抗指数、CRP是影响大动脉僵硬度的主要因素。结论 2型糖尿病病人中高血压、高脂血症的发生率明显高于正常人群,颈动脉更易生长斑块,且大动脉弹性明显减退,影响其僵硬度的因素有年龄、收缩压、LDL-C、胰岛素抵抗指数、CRP等。应在治疗中严格控制多重危险因素,提高治疗效果,改善病人生活质量。
[Abstract]:Objective to analyze the arterial stiffness and its related risk factors in type 2 diabetes mellitus. Methods 582 patients with type 2 diabetes treated in Shougang Hospital of Peking University from September 2013 to September 2016 were selected as the observation group, and 384 normal subjects were selected as the control group. General data, carotid ultrasound and pulse wave velocity were collected and compared between the two groups. Results the systolic blood pressure (SBP), triglyceride-triglyceride (TGG), body mass index (mass), low density lipoprotein cholesterol (LDL-C), insulin resistance index (ISR) C reactive protein, and homocysteine in the observation group were higher than those in the control group. High density lipoprotein cholesterol (HDL-C) of high density lipoprotein cholesterol (HDL-C) was significantly lower in the two groups than that in the control group (P 0.05). The carotid intima-media thicknessen IMT, carotid artery pulse wave velocities (CF-PWV) in the observation group were higher than those in the control group (P 0.05). The detection rate of unilateral plaque in the observation group was 47.59 and that in the control group was 14.22. The detection rate of the bilateral carotid artery plaque in the observation group was 47.59 and 14.22. The detection rate of the bilateral carotid artery plaque in the observation group was 47.59, and that in the control group was 14.22. 33.85, the control group was 5.47, single, The bilateral observation group was higher than the control group, and the difference between the two groups was statistically significant (P 0.05). Logistic regression analysis of pulse wave velocity in patients with type 2 diabetes mellitus showed that age, systolic pressure, LDL-C and insulin resistance index were the main factors affecting arterial stiffness. Conclusion the incidence of hypertension and hyperlipidemia in patients with type 2 diabetes is significantly higher than that in normal subjects. Carotid artery is more likely to grow plaque, and the elasticity of large arteries is obviously decreased. Age is the factor that affects the stiffness of hypertension and hyperlipidemia. Systolic blood pressure, LDL-C, insulin resistance index, CRP and so on. Multiple risk factors should be strictly controlled in the treatment to improve the effect of treatment and improve the quality of life of the patients.
【作者单位】：北京大学第三医院放射科;北京市第一中西医结合医院放射科;北京大学首钢医院血管医学科;
【基金】：北京市卫生局首都卫生发展科研专项(首发2011-4026-02) 北京大学首钢医院院内基金(SGYY201406)~~
【分类号】：R587.2

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