240例男性代谢综合征高危因素人群胰岛功能评价

发布时间：2018-04-22 17:46

本文选题：代谢综合征 + 男性人群　；参考：《基因组学与应用生物学》2017年05期

【摘要】：评估代谢综合征(MS)高危因素人群胰岛β细胞生理作用情况(分泌,抵抗),为早期预防提供参考依据。2014年3月~2015年3月收集我院体检人群数据,入选240例MS高危男性受试者。通过口服葡萄糖耐量试验和胰岛素刺激试验,空腹及糖负荷后1/2 h和2 h两个时间的的血糖、胰岛素及C肽水平将被观察检测,从而评估胰岛β细胞功能及胰岛素抵抗情况。OGTT结果表明血糖正常组、糖尿病前期组和伴糖尿病组MS患者分别为148例(61.7%)、76例(31.7%)、16例(6.6%)。各组血糖、胰岛素和C肽的体内变化曲线发现各组的指标随着时间慢慢升高后缓慢下降,最后趋于平缓。餐后1/2 h和2 h时间点,发现血糖异常的两组胰岛素及C肽仅I_(2h)、C_(1/2h)及C_(2h)与正常组相比具有一定差异,且C_(1/2h)与正常组相比有下降趋势,I_(2h)、C_(2h)与正常组相比则有所提高。伴糖尿病的MS患者胰岛素抵抗指标HOMA-IR、IAI、ISIc显著高于正常血糖的MS患者。与正常血糖MS患者相比,糖尿病前期MS患者和伴糖尿病MS患者的HBCI、IGI都显著降低。综上所述,MS人群虽然FBG早期未出现紊乱现象,当给予糖负荷后,其血糖发生异常变化,该危险不容忽视。MS患者具有潜在的糖尿病风险,因此,通过探讨MS高危人群的胰岛分泌功能及胰岛素抵抗情况,对早期预防有一定指导价值。
[Abstract]:To evaluate the physiological function of islet 尾 cells (secretion, resistance) in the population with high risk factors of metabolic syndrome (MSM), to provide reference for early prevention. Data of physical examination in our hospital from March 2014 to March 2015 were collected and 240 male subjects with high risk of MS were selected. By oral glucose tolerance test and insulin stimulation test, blood glucose, insulin and C-peptide levels were observed at fasting and at 1 / 2 and 2 h after glucose load. The results of evaluation of islet 尾 cell function and insulin resistance showed that there were 148 patients with MS in normal blood glucose group, 76 patients with diabetes mellitus and 76 patients with diabetes mellitus. The changes of blood glucose, insulin and C-peptide in each group showed that the indexes of each group decreased slowly and then decreased slowly with time. At 1 / 2 h and 2 h postprandial, it was found that the two groups with abnormal blood glucose only had 2 hs of serum insulin and C peptide (I / P = 1 / 2 h) and 2 h) and compared with the normal group, there was a certain difference between the two groups (compared with the normal group), and compared with the normal group, there was a tendency to decrease the tendency of the decrease of the level of Istin and C peptide in the two groups (compared with the normal group for 2 h), there was an increase in the level of Istix (2 h) compared with the normal group (P < 0.05). Insulin resistance in MS patients with diabetes was significantly higher than that in MS patients with normal blood glucose. Compared with normal glucose MS patients, the HBCIIGI levels in both pre-diabetic MS patients and diabetic MS patients were significantly lower. In conclusion, although there is no disorder in FBG early in MS population, abnormal changes of blood glucose occur when given glucose load. The risk can not be ignored. The risk of MS patients has potential diabetes risk, therefore, The study of pancreatic islet secretory function and insulin resistance in high risk population of MS has certain guiding value for early prevention.
【作者单位】：广州医科大学附属第一医院;
【分类号】：R589

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