固力康联合鲑鱼降钙素治疗老年性骨质疏松的临床疗效及安全性

发布时间：2018-04-22 19:49

本文选题：固力康 + 鲑鱼降钙素　；参考：《中国骨质疏松杂志》2017年05期

【摘要】：目的对固力康联合鲑鱼降钙素治疗老年性骨质疏松的临床疗效及安全性进行分析。方法选取2014年9月至2016年1月于我院治疗的122例老年性骨质疏松患者进行研究,按照患者入院时间进行分成两组,治疗组、对照组分别61例,给予对照组患者鲑鱼降钙素进行治疗,治疗组患者给予固力康联合鲑鱼降钙素进行治疗,在治疗6月后,将两组患者的疼痛VAS评分、腰椎及髋部骨密度、骨钙素(BGP)和β-胶原降解产物(β-Cross Laps)变化情况进行对比,同时对患者服药后的不良反应发生率进行比较。结果治疗6个月后两组患者VAS评分均较治疗前有明显改善(P0.05),且治疗组患者评分明显低于对照组(P0.05)。治疗6个月后,两组患者骨密度较治疗前都显著改善(P0.05),血清BGP和β-Cross Laps较治疗前有显著改变(P0.05),且均明显优于对照组(P0.05)。两组药品不良反应发生率比较,差异无统计学意义(P0.05)。结论固力康联合鲑鱼降钙素治疗老年性骨质疏松效果显著,安全性较高,值得在临床中推广应用。
[Abstract]:Objective to analyze the efficacy and safety of Gulikang combined with salmon calcitonin in the treatment of senile osteoporosis. Methods A total of 122 patients with senile osteoporosis treated in our hospital from September 2014 to January 2016 were selected and divided into two groups according to their admission time: the treatment group (n = 61) and the control group (n = 61). The patients in the control group were treated with salmon calcitonin, and the patients in the treatment group were treated with Gulikang combined with salmon calcitonin. After 6 months of treatment, the VAS score of pain, bone mineral density of lumbar vertebra and hip were measured. The changes of BGP and 尾 -Cross Lapswere compared, and the incidence of adverse reactions after taking BGP was compared. Results after 6 months of treatment, the VAS scores of the two groups were significantly improved compared with those before treatment, and the scores of the patients in the treatment group were significantly lower than those in the control group (P 0.05). After 6 months of treatment, the bone mineral density (BMD) of the two groups was significantly improved than that of the control group (P 0.05). The serum BGP and 尾 -Cross Laps were significantly different from those of the control group (P 0.05), and were significantly better than that of the control group (P 0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups (P 0.05). Conclusion Gulikang combined with salmon calcitonin is effective and safe in the treatment of senile osteoporosis.
【作者单位】：重庆两江新区第一人民医院;
【分类号】：R580

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