代谢综合征及其各组分与骨质疏松性骨折的相关性研究

发布时间：2018-04-23 07:52

本文选题：骨质疏松症性骨折 + 代谢综合征X　；参考：《中国全科医学》2017年08期

【摘要】：目的了解贵阳市40岁及以上居民代谢综合征(MS)及其各组分与骨质疏松性骨折的相关性。方法选取2011年贵阳市云岩区参与慢性病调查的40岁及以上人群9 908例为研究对象。采用自制问卷调查受试者信息,包括性别、年龄、生活习惯、既往病史、骨质疏松性骨折史,测量受试者身高、体质量、腰围、血压,检测空腹血糖(FPG)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)水平。结果 9 908例受试者MS患病率为23.87%(2 365/9 908),骨质疏松性骨折史检出率为17.65%(1 749/9 908)。男性受试者中,骨折组与非骨折组年龄、未饮茶、未饮酒、饮牛奶比例、体质指数(BMI)、MS患病率、腰围、收缩压、舒张压以及FPG、TG、HDL-C水平比较,差异均无统计学意义(P0.05)。女性受试者中骨折组年龄、饮牛奶比例、BMI、MS患病率、腰围、收缩压、TG水平均高于非骨折组,HDL-C水平低于非骨折组(P0.05)。多因素Logistic回归分析显示,校正年龄、饮茶、饮酒、饮牛奶、BMI等混杂因素后,未发现MS及其各组分与男性受试者骨质疏松性骨折有关(P0.05),而MS〔OR=1.224,95%CI(1.065,1.407)〕、中心性肥胖〔OR=1.399,95%CI(1.187,1.647)〕、高水平TG〔OR=1.273,95%CI(1.121,1.446)〕、低水平HDL-C〔OR=1.142,95%CI(1.009,1.294)〕是女性受试者发生骨质疏松性骨折的危险因素(P0.05)。结论 MS及其组分中心性肥胖、血脂异常是40岁及以上女性发生骨质疏松性骨折的危险因素。
[Abstract]:Objective to investigate the correlation between metabolic syndrome (MSM) and osteoporosis fracture in residents aged 40 and over in Guiyang. Methods 9 908 people aged 40 years and above who participated in the investigation of chronic diseases in Yunyan District of Guiyang City in 2011 were selected as the study objects. A self-made questionnaire survey was conducted to measure the subjects' height, body mass, waist circumference, blood pressure, including gender, age, life habits, past medical history, osteoporosis fracture history, and so on. Fasting blood glucose levels of FPGN, triglyceride TGN and high density lipoprotein cholesterol (HDL-C) were measured. Results the prevalence of MS in 9 908 subjects was 23.87%, and the detection rate of osteoporosis fracture history was 17.65% / 9,908%. In male subjects, there was no significant difference between fracture group and non-fracture group in age, no tea drinking, drinking milk, body mass index (BMI), prevalence rate of BMI-MS, waist circumference, systolic blood pressure, diastolic blood pressure and FPGG TGG level of HDL-C. The age of fracture group, the prevalence rate of BMIMS, waist circumference and systolic blood pressure (TG) in female subjects were higher than those in non-fracture group (P 0.05). Multivariate Logistic regression analysis showed that after adjusting for age, drinking tea, drinking alcohol, drinking milk and other mixed factors, there was no correlation between MS and its components with osteoporosis fracture in male subjects (P 0.05). The high level of TGG was 1.273C95. The risk factors of osteoporosis fracture in female subjects were 1.121 ~ 1.446, and 1.142 ~ 1.142 ~ (95) ~ 1.294C ~ (-1) ~ (-1) ~ 0. 05 ~ 0. 05 ~ 0. 05 ~ 0. 05 ~ 0. 05 ~ 0. 05 ~ 0. 05 ~ 0. 05 ~ 0. 05 ~ 0. 05 ~ 0. 05 ~ 0. 05 ~ 0. 05, respectively. Conclusion MS and its compositional obesity and dyslipidemia are risk factors for osteoporotic fracture in women aged 40 and above.
【作者单位】：贵州医科大学附属医院内分泌代谢病科;
【基金】：贵州省科技厅社会攻关计划[黔科合LG字(2011)016号] 贵州省优秀科技教育人才省长专项资金项目[黔省专合字(2010)82号]
【分类号】：R58;R683

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