糖尿病黄斑水肿玻璃体内注射康柏西普的短期疗效和椭圆体带完整性改变的观察

发布时间：2018-04-24 18:11

本文选题：糖尿病视网膜病变 + 黄斑水肿　；参考：《眼科新进展》2017年11期

【摘要】：目的评估糖尿病黄斑水肿(diabetic macular edema,DME)患者玻璃体内注射康柏西普的短期疗效并观察椭圆体带(ellipsoid zone,EZ)完整性改变情况。方法 DME患者14例(16眼),所有患眼均行玻璃体内注射康柏西普治疗。在注射后1个月、2个月、3个月时分别复查最佳矫正视力(best corrected visual acuity,BCVA)、光学相干断层扫描(optical coherence tomography,OCT)。比较注射前与注射后1个月、2个月、3个月的log MAR BCVA、黄斑体积和黄斑中心凹视网膜厚度(central foveal thickness,CFT)以及注射前与注射后3个月的中心凹EZ不完整部分的横断面长度。结果患眼注射前log MAR BCVA为0.79±0.08,CFT为(536.44±35.87)μm,黄斑体积为(11.27±0.37)mm~3。注射后1个月患眼log MAR BCVA为(0.65±0.07),CFT为(385.63±22.60)μm,黄斑体积为(10.21±0.22)mm~3。注射后2个月患眼log MAR BCVA为0.56±0.06,CFT为(336.13±21.91)μm,黄斑体积为(9.69±0.17)mm~3。注射后3个月患眼log MAR BCVA为0.52±0.06,CFT为(292.38±22.54)μm,黄斑体积为(9.30±0.20)mm~3。两两比较差异均有统计学意义(均为P0.05)。所有患者注射前通过黄斑中心凹的EZ不完整部分的横断面长度为(3116.69±385.55)μm,3次注射后为(1784.88±362.39)μm,差异有统计学意义(P0.05)。结论玻璃体内注射康柏西普可以减轻黄斑水肿,提高患者视力,改善黄斑区椭圆体带完整性。
[Abstract]:Objective to evaluate the short-term efficacy of intravitreal injection of Compactopril in patients with diabetic macular edema (macular edema) and to observe the changes of ellipsoid zoneidone (EZ) integrality in patients with diabetic macular edema (DM). Methods 14 cases (16 eyes) with DME were treated with intravitreous injection of Combortopril. At 1 month, 2 months and 3 months after injection, the best corrected visual acuity and optical coherence tomography were examined respectively. Log MAR BCVA, macular volume and retinal thickness of central fovea were compared before injection and 1 month, 2 months and 3 months after injection, and the cross-sectional length of incomplete part of EZ in fovea before injection and 3 months after injection were compared. Results the log MAR BCVA and macular volume were 0.79 卤0.08 卤56.44 卤35.87 渭 m and 11.27 卤0.37 渭 m, respectively. One month after injection, the log MAR BCVA was 0.65 卤0.07 渭 m and the macular volume was 10.21 卤0.22 mm ~ (-1) 渭 m. 2 months after injection, the log MAR BCVA was 0.56 卤0.06 渭 m and the macular volume was 9.69 卤0.17 mm ~ (-1) 渭 m. 3 months after injection, the log MAR BCVA was 0.52 卤0.06 渭 m and the macular volume was 9.30 卤0.20 渭 m. The differences were statistically significant (P 0.05). The cross section length of the incomplete part of EZ passed through the fovea of macula before injection was 3116.69 卤385.55 渭 m and 1784.88 卤362.39 渭 m after 3 injections. The difference was statistically significant (P 0.05). Conclusion intravitreous injection of Compactopril can reduce macular edema, improve visual acuity and improve the integrity of ellipsoid zone in macular area.
【作者单位】：首都医科大学附属北京安贞医院;北京大学国际医院眼科;
【分类号】：R587.2;R774

【相似文献】