复方黄杞汤剂联合溴化吡啶斯的明治疗重症肌无力临床研究

发布时间：2018-04-24 17:41

本文选题：重症肌无力 + 痿证　；参考：《辽宁中医药大学》2017年硕士论文

【摘要】：目的:观察复方黄杞汤剂联合溴化吡啶斯的明治疗I型、IIa型及IIb型重症肌无力患者的临床疗效,为临床提供切实可行的治疗方法。材料与方法:将60例I型、IIa型及IIb型重症肌无力患者按照随机数字表随机化分组的方式分为试验组(复方黄杞汤剂联合溴化吡啶斯的明治疗组)和对照组(溴化吡啶斯的明治疗组),试验组30例:男患13例,女患17例,年龄10-75岁,平均年龄:48.8岁,病程1-97个月;对照组30例:男患14例,女患16例,年龄8-75岁,平均年龄:55,病程2-96个月。两组均应用溴化吡啶斯的明治疗,试验组服用溴化吡啶斯的明同时加用复方黄杞汤剂治疗,治疗前及治疗6个月后,两组患者均采用重症肌无力绝对评分表及中医症状评分表评定,观察比较两组患者临床症状的改善情况,数据应用SPSS17.0统计软件进行统计处理,计量资料用均数±标准差表示,对数据首先进行正态分布检验,样本符合正态分布者应用t检验,不符合正态分布者应用秩和检验,计数材料应用R×C卡方检验,均以P0.05为有差异的标准,具有统计学的意义。结果:1.将两组患者性别、年龄、分型、病程、重症肌无力临床绝对评分及中医症状评分等资料进行统计分析后P值均大于0.05,表明两组患者治疗前具有可比性。2.经过6个月的治疗后,对两组患者再次进行重症肌无力临床绝对评分及中医症状评分,经过统计分析后,P值均小于0.05,说明两组重症肌无力临床绝对评分及中医症状评分具有可比性,存在统计学意义。3.试验组在缓解I型、IIa型及IIb型重症肌无力患者的临床疗效方面优于对照组,组间差异有统计学意义(P0.05)。结论:复方黄杞汤剂联合溴化吡啶斯的明可以明显缓解I型、IIa型及IIb型重症肌无力患者的临床症状。
[Abstract]:Objective: to observe the clinical effect of compound Huangqi decoction combined with pyridamine bromide in the treatment of myasthenia gravis type I and IIb. Materials and methods: 60 patients with myasthenia gravis type I and IIb were randomly divided into two groups: the experimental group (treated with compound Huangqi decoction combined with pyridinium bromide) and the control group (brominated). Pyridamine treatment group (n = 30): 13 males, There were 17 female patients aged 10-75 years (mean age: 48.8 years, course of disease 1-97 months) and 30 cases in control group (14 males, 16 females, 8-75 years old, mean age: 55, 2-96 months). Both groups were treated with pyridamine bromide, while those in the experimental group were treated with compound Huangqi decoction before and after 6 months of treatment. The patients in both groups were assessed with the absolute score table of myasthenia gravis and the Chinese medicine symptom score table. The improvement of clinical symptoms was observed and compared between the two groups. The data were statistically processed by SPSS17.0 statistical software, and the measured data were expressed as mean 卤standard deviation. The data were tested with normal distribution, the samples were tested with t test, those with normal distribution were tested by rank sum test, and the counting materials were tested by R 脳 C chi-square test, all of them were based on the standard of P0.05, which had statistical significance. The result is 1: 1. The data of sex, age, classification, course of disease, clinical absolute score of myasthenia gravis and TCM symptom score were analyzed statistically in the two groups (P > 0.05), which indicated that the two groups were comparable before treatment. After 6 months of treatment, the patients in both groups were given the absolute clinical score of myasthenia gravis and the TCM symptom score again. After statistical analysis, P values were less than 0.05, indicating that the two groups of myasthenia gravis clinical absolute score and TCM symptom score are comparable, there is statistical significance. 3. The treatment group was superior to the control group in relieving the clinical efficacy of type I and IIb type myasthenia gravis, and the difference between the two groups was statistically significant (P 0.05). Conclusion: compound Huangqi decoction combined with pyridamine bromide can significantly relieve the clinical symptoms of patients with myasthenia gravis of type I and type II and IIb.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R746.1

【参考文献】