低剂量阿仑膦酸钠配合鼓励教育对骨质疏松症患者服药依从性的影响

发布时间：2018-04-25 15:04

  本文选题：阿仑膦酸钠 + 膦酸类　； 参考：《中国新药与临床杂志》2017年06期

【摘要】：目的研究低剂量阿仑膦酸钠配合鼓励教育是否能提高骨质疏松症患者服药依从性。方法 210例已接受阿仑膦酸钠常规剂量治疗半年的骨质疏松症妇女随机分为干预组与对照组,干预组(n=105)给予低剂量阿仑膦酸钠(70 mg,2周1次)治疗;对照组(n=105)为常规剂量(70 mg,每周1次)治疗。两组均依据入组前后骨转换指标变化,教育鼓励患者坚持服药。观察两组治疗6、12、18个月时的服药顺应性、服药持续性和不良反应。运用治疗期间的药物持有率(MPR)判断患者服药顺应性,MPR≥80%为服药有顺应性;采用治疗期间开始用药至终止用药的天数表达患者服药持续性,停药间隔超过30 d判断为终止用药。结果在第12个月和18个月随访期,干预组MPR中位数均高于对照组(P0.05)。在第6个月随访期干预组和对照组的有服药顺应性的患者比例分别为89.5%和76.2%(P=0.010);在第12个月随访期分别为73.3%和58.1%(P=0.020);在第18个月随访期分别为67.6%和48.6%(P=0.005),两组比较均有显著差异。同样,随访期第12个月和第18个月干预组持续服药天数中位数也均高于对照组,分别为360(225,360)d和360(120,360)d(P=0.030),540(225,540)d和390(120,540)d(P=0.002)。结论低剂量阿仑膦酸钠(70 mg,2周1次)口服配合鼓励教育能提高骨质疏松症患者服药依从性。
[Abstract]:Objective to study whether low-dose alendronate combined with encouraging education can improve the compliance of osteoporosis patients. Methods 210 osteoporosis women who had been treated with alendronate for half a year were randomly divided into two groups: intervention group (n = 105) and control group (n = 10 5). The control group (n = 105) was treated with a routine dose of 70 mg once a week. According to the changes of bone turnover index before and after entering the two groups, the patients were encouraged to take medicine. The drug compliance, drug persistence and adverse reactions were observed in the two groups at 12 and 18 months after treatment. According to the drug holding rate and MPRs during the treatment period, the patients' compliance was judged by MPR 鈮，

本文编号：1801830