尿促性素联合枸橼酸氯米芬对多囊卵巢综合征患者的影响

发布时间：2018-04-28 12:44

本文选题：多囊卵巢综合征 + 尿促性素　；参考：《中国全科医学》2017年S1期

【摘要】：目的探讨尿促性素(HMG)联合枸橼酸氯米芬(CC)对多囊卵巢综合征(PCOS)患者排卵周期、子宫内膜、卵泡情况、激素、卵巢过度刺激综合征及妊娠的影响。方法选取2012年6月—2015年6月温州医学院附属第三医院妇产科收治的160例PCOS患者,按照随机数字表的方法将所有患者分为研究组和对照组。对照组给予CC,研究组在此基础上给予HMG。比较两种治疗方案对患者排卵周期、子宫内膜、卵泡情况、激素、卵巢过度刺激综合征及妊娠的影响。结果研究组患者的子宫内膜厚度和成熟卵泡数均高于对照组(t=21.939,9.778,P0.05);两组患者的最大卵泡直径、有排卵周期数比较,差异无统计学意义(t=0.812,χ~2=2.609,P0.05);研究组患者的雌二醇(E2)水平高于对照组(t=3.567,P0.05);两组患者的黄体生成激素(LH)以及睾酮(T)的水平比较,差异无统计学意义(t=0.539,0.599,P0.05);研究组患者的平均用药周期短于对照组(P0.05)、临床妊娠率高于对照组,差异有统计学意义(P0.05);两组患者的流产率、多胎妊娠率、OHSS发生率比较,差异均无统计学意义(P0.05)。结论 HMG联合CC治疗PCOS,用药周期短,促排卵效果显著,具有较高的临床妊娠率,值得推广应用。
[Abstract]:Objective to investigate the effects of urinal gonadotropin (HMG) combined with clomiphene citrate (CCC) on ovulation cycle, endometrium, follicle status, hormones, ovarian hyperstimulation syndrome and pregnancy in patients with polycystic ovary syndrome (PCOS). Methods from June 2012 to June 2015, 160 patients with PCOS in gynecology and obstetrics department of the third affiliated Hospital of Wenzhou Medical College were randomly divided into study group and control group. The control group was given CCS, and the study group was given HMG-based. The effects of two treatments on ovulation cycle, endometrium, follicle status, hormones, ovarian hyperstimulation syndrome and pregnancy were compared. Results the thickness of endometrium and the number of mature follicles in the study group were higher than those in the control group (21.939 ~ 9.778g / P 0.05), the maximum follicle diameter and the number of ovulation cycles were compared between the two groups. The level of estradiol E _ 2 in the study group was higher than that in the control group, and the levels of luteinizing hormone (LH) and testosterone (T) in the two groups were higher than those in the control group, the difference was not significant (P = 0.812), and the level of estradiol E _ (2) in the study group was higher than that in the control group (P _ (0.05). There was no significant difference between the two groups (P 0.05). The average period of medication in the study group was shorter than that in the control group (P 0.05), and the clinical pregnancy rate was higher than that in the control group (P 0.05). The abortion rate and the multiple pregnancy rate of the two groups were higher than those of the control group, and the incidence of OHSS was higher than that of the control group. The difference was not statistically significant (P 0.05). Conclusion the combination of HMG and CC in the treatment of PCOS has the advantages of short medication cycle, obvious effect of ovulation promotion, and high clinical pregnancy rate, which is worth popularizing.
【作者单位】：温州医学院附属第三医院;温州医科大学附属第一医院;
【分类号】：R711.75

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