1.8mT不同频率正弦交变电磁场对青年大鼠骨密度及骨形态计量的影响比较

发布时间：2018-04-29 04:14

本文选题：骨密度 + 正弦交变电磁场　；参考：《生物工程学报》2017年07期

【摘要】：比较不同频率的正弦交变电磁场对SD青年大鼠骨密度及骨形态计量指标的影响,筛选可有效提升大鼠骨密度的频率参数。将32只8周龄SD雌性大鼠随机分为4组:对照组、15 Hz组、30 Hz组、45 Hz组;除对照组外,实验组大鼠每天都给予相应频率的1.8 m T正弦交变电磁场干预,干预时间为90 min。磁场干预8周后,双能X射线骨密度仪检测大鼠全身骨密度、右侧股骨骨密度和椎骨骨密度,ELISA分析血清中骨形成与骨吸收生化指标的含量,右侧胫骨进行荧光间距测量与骨形态计量分析。相比于对照组,15 Hz组、45 Hz组大鼠的全身骨密度、股骨骨密度、椎骨骨密度均明显升高(P0.05),血清中骨钙素与骨保护素含量也显著提升(P0.05);实验组大鼠的胫骨双荧光间距与骨组织静态参数均高于对照组(P0.05)。结果表明,15 Hz、45 Hz正弦交变电磁场可有效提升青年大鼠的骨密度,从而可预防骨质疏松的发生。
[Abstract]:The effects of sinusoidal electromagnetic field on bone mineral density and bone morphometry of SD young rats were compared, and the frequency parameters of bone mineral density could be improved effectively. 32 8 week old SD female rats were randomly divided into 4 groups: control group, 15 Hz group, 30 Hz group, 45 Hz group; the experimental group was given 1 of the corresponding frequency except for the group. .8 m T sinusoidal electromagnetic field intervention, intervention time of 90 min. magnetic field intervention for 8 weeks, double energy X ray bone densitometer to detect the whole body bone density, right femur bone density and bone mineral density, ELISA analysis of serum bone formation and bone absorption biochemical index content, the right tibia fluorescence distance measurement and bone morphometric analysis. In the control group, the total bone mineral density, the bone mineral density and the bone mineral density in the 15 Hz group and the 45 Hz group increased significantly (P0.05), and the serum osteocalcin and osteoprotegerin content also increased significantly (P0.05). The tibial double fluorescent spacing and the static parameters of the bone tissue in the experimental group were higher than those of the control group (P0.05). The results showed that 15 Hz, 45 Hz sinusoidal alternating electricity. Magnetic field can effectively enhance bone mineral density in young rats, thus preventing osteoporosis.

【作者单位】：兰州理工大学生命科学与工程学院;
【基金】：国家自然科学基金(Nos.81270963,81471090)资助~~
【分类号】：R580

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