中青年糖尿病合并颈动脉斑块的危险因素分析

发布时间：2018-04-29 04:37

  本文选题：中青年 + 糖尿病　； 参考：《延边大学》2017年硕士论文

【摘要】：目的:分析中青年糖尿病合并颈动脉斑块形成的相关危险因素,为有效干预中青年糖尿病大血管并发症的发生、发展提供临床依据。对象及方法:选择2014年1月至2016年9月,在延边大学附属医院健康体检中心体检并行颈动脉彩超的18-60岁中青年糖尿病人群按颈动脉彩超结果,分为CAP组(IMT≥1.5mm),共202例和非CAP组(IMT1.5mm),共200例及健康组174例。每一受试者记录身高、体重、血压和空腹血糖、血脂、尿酸等进行测量和分析。结果:1.糖尿病组颈动脉斑块形成显著高于健康组,且不同年龄段间高龄段颈动脉斑块增加,差异有统计学意义(P0.05)。3.糖尿病组的一般资料及生化指标均高于健康组,差异有统计学意义(P0.01);糖尿病组亚组,CAP组与非CAP组间总胆固醇、低密度脂蛋白、空腹血糖、收缩压及糖尿病病史有明显差异(P0.05)。4.糖尿病合并颈动脉斑块形成男性与女性间有明显差异(P0.01);吸烟年限≤15年和吸烟年限15年间颈动脉斑块形成差异有统计学意义(P0.01)。5.Logistic回归分析结果示,校正了其他因素之后,低密度脂蛋白、收缩压、空腹血糖、糖尿病病史及吸烟年限是糖尿病合并颈动脉斑块形成的独立危险因素(0R 1.804,95%CI(1.304-2.496),P0.01;0R 1.022,95%CI(1.010-1.033),P0.01;OR 1.169,95%CI(1.054-1.297),P0.05;OR 1.174,95%CI(1.096-1.252),P0.01;OR 1.190,95%CI(1.101-1.278),P0.01))。结论:1.糖尿病患者FBG及糖尿病病史是颈动脉斑块形成重要的危险因素之一。2.高龄、SBP、TC、LDL-C、超重及吸烟年限等,也可显著影响中青年糖尿病合并颈动脉斑块的形成。3.男性中青年糖尿病患者颈动脉斑块形成风险高于女性。
[Abstract]:Objective: to analyze the risk factors related to the formation of carotid plaque in young and middle-aged diabetes mellitus, and to provide clinical basis for effective intervention on the occurrence and development of macrovascular complications in young and middle-aged diabetes mellitus. Participants and methods: from January 2014 to September 2016, a group of young and middle-aged diabetic subjects aged 18-60 years with diabetes mellitus aged 18-60 years were examined by carotid artery color Doppler ultrasound at the Health examination Center of Yanbian University affiliated Hospital. The patients were divided into two groups: CAP group (n = 202) and non CAP group (n = 200) and healthy group (n = 174). Height, weight, blood pressure and fasting blood glucose, blood lipids, uric acid were measured and analyzed. The result is 1: 1. Carotid plaque formation in diabetic group was significantly higher than that in healthy group, and carotid plaque in elderly patients increased in different age groups, and the difference was statistically significant (P 0.05. 3). The general data and biochemical indexes of diabetic group were higher than that of healthy group, the difference was statistically significant (P 0.01), and there were significant differences in total cholesterol, low density lipoprotein, fasting blood glucose, systolic blood pressure and history of diabetes mellitus between CAP group and non CAP group. There was a significant difference between male and female in the formation of carotid plaque in diabetes mellitus (DM), and significant difference in plaque formation in carotid artery between male and female during the period of smoking 鈮，

本文编号：1818440