红细胞分布宽度预测2型糖尿病患者支架内再狭窄

发布时间：2018-04-29 15:43

本文选题：红细胞分布宽度 + 型糖尿病　；参考：《中国动脉硬化杂志》2017年12期

【摘要】：目的探讨红细胞分布宽度(RDW)对皮冠状动脉介入治疗(PCI)的2型糖尿病患者植入药物洗脱支架后发生支架内再狭窄(ISR)的预测价值。方法回顾性分析因不稳定型心绞痛入院、行PCI治疗植入药物洗脱支架的582例2型糖尿病患者的临床资料,其中292例在支架植入术后进行了冠状动脉造影随访,平均随访8个月。根据冠状动脉造影检查结果,将患者分为支架内再狭窄组(n=45)和非再狭窄组(n=247)。详细记录患者病史资料(年龄、性别、吸烟、既往病史)、实验室检查结果(RDW、C反应蛋白水平等),以及心脏彩超、冠状动脉造影等结果。结果 ISR组体质指数和吸烟史均比非ISR组高(P0.05)。ISR组RDW、C反应蛋白水平在入院和随访时均比非ISR组高。与非ISR组相比,ISR组的支架长度更长、直径更小。单因素分析显示,RDW与ISR呈正相关(P0.01)。多元回归分析显示,体质指数、吸烟、RDW、C反应蛋白、支架长度、支架直径是药物洗脱支架ISR的预测因子(P0.01)。结论糖尿病患者在具备同样的危险因素情况下,RDW对植入药物洗脱支架的不稳定型心绞痛患者发生ISR有预测作用,慢性炎症参与了ISR的形成过程。
[Abstract]:Objective to investigate the predictive value of RDW in patients with type 2 diabetes mellitus after percutaneous coronary intervention (PCI). Methods the clinical data of 582 patients with type 2 diabetes mellitus who were treated with PCI for unstable angina pectoris were retrospectively analyzed. Among them, 292 patients were followed up by coronary angiography after stent implantation, with an average follow-up of 8 months. According to the results of coronary angiography, the patients were divided into stenting restenosis group (n = 45) and non-restenosis group (n = 247). The data of patients' history (age, sex, smoking, past medical history, laboratory results, RDWN C-reactive protein level, color Doppler echocardiography, coronary arteriography, etc.) were recorded in detail. Results the body mass index (BMI) and smoking history of ISR group were higher than those of non- group. The level of RDWN C-reactive protein in ISR group was higher than that in non- group at admission and follow-up. The length and diameter of stents in the ISR group were longer and smaller than those in the non-ISR group. Univariate analysis showed that there was a positive correlation between RDW and ISR (P 0.01). Multiple regression analysis showed that body mass index (BMI), RDWN C-reactive protein (CRP), stent length and stent diameter were the predictors of ISR in drug-eluting stents (P 0.01). Conclusion RDW can predict the occurrence of ISR in patients with unstable angina pectoris with drug-eluting stents under the same risk factors. Chronic inflammation is involved in the formation of ISR.
【作者单位】：天津市南开医院心血管内科;
【基金】：国家自然科学基金青年项目(81503409)
【分类号】：R541.4;R587.1

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