2型糖尿病与血清基质细胞衍生因子-1水平的相关性

发布时间：2018-04-29 17:46

  本文选题：型糖尿病 + 基质细胞衍生因子-　； 参考：《实用医学杂志》2017年17期

【摘要】：目的探讨2型糖尿病(T2DM)与血清基质细胞衍生因子-1(SDF-1)水平的关系。方法采用现场流行病学调查的方法,对北京市某区40岁及以上的社区居民进行问卷调查、体格检查及SDF-1等指标检测。研究共纳入756例研究对象,包括T2DM患者267例及非T2DM患者489例,并根据有无大血管并发症将T2DM患者分为单纯T2DM组81例和合并大血管病变组186例,进而分析T2DM与血清SDF-1水平的相关性。结果组间比较分析显示,T2DM患者血清SDF-1水平高于非患者组(P=0.019)。进一步对比单纯T2DM组及合并大血管病变组,结果显示单纯T2DM患者SDF-1水平高于合并大血管病变组(P=0.044)。多元线性回归分析显示,调整年龄、性别、吸烟、饮酒、高血压、血脂异常和BMI后,单纯T2DM患者SDF-1水平仍高于合并大血管病变患者(P=0.049)。结论单纯T2DM患者SDF-1水平高于非T2DM患者及T2DM合并大血管病变患者,提示SDF-1可能与T2DM及T2DM合并大血管病变存在一定的相关性。
[Abstract]:Objective to investigate the relationship between type 2 diabetes mellitus T 2 DM and serum stromal cell derived factor-1 (- 1) SDF-1. Methods the community residents aged 40 and above in a certain district of Beijing were investigated with questionnaire, physical examination and SDF-1. A total of 756 patients were included in the study, including 267 patients with T2DM and 489 patients without T2DM. According to whether there were macrovascular complications, T2DM patients were divided into simple T2DM group (81 cases) and complicated macrovascular disease group (186 cases). The correlation between T2DM and serum SDF-1 level was analyzed. Results the serum SDF-1 level of T2DM patients was higher than that of non-patient group (P < 0. 019). The results showed that the level of SDF-1 in patients with T2DM was higher than that in patients with macroangiopathy. Multiple linear regression analysis showed that after adjusting for age, sex, smoking, alcohol consumption, hypertension, dyslipidemia and BMI, the level of SDF-1 in patients with simple T2DM was still higher than that in patients with macrovascular disease. Conclusion the level of SDF-1 in simple T2DM patients is higher than that in non- patients and T2DM patients with macroangiopathy, suggesting that SDF-1 may be correlated with T2DM and T2DM with macroangiopathy.
【作者单位】： 北京大学公共卫生学院;
【基金】：国家自然科学基金重点资助项目(编号:81230066);国家自然科学基金资助项目(编号:81102177,8172744,81473043)
【分类号】：R587.2
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本文编号：1820939