老年糖尿病患者角膜内皮细胞形态和角膜厚度的动态变化

发布时间：2018-04-29 19:14

本文选题：糖尿病 + 角膜内皮细胞形态　；参考：《中国老年学杂志》2017年23期

【摘要】：目的探讨老年糖尿病(DM)患者角膜内皮细胞形态和角膜厚度的动态变化。方法 2型糖尿病(T2DM)患者28例(56只眼)为DM组,28名(56只眼)健康志愿者为对照组,对所有受试对象角膜中央区域的角膜内皮细胞变异系数(CV)、平均密度(CD)、六边形细胞比例(6A%)及中央角膜厚度(CCT)、角膜中心外1.5 mm及3.0 mm厚度,进行检测及定量分析。拍摄角膜内皮细胞图像进行分析。结果与对照组比,DM组CCT、中心外1.5 mm及3.0 mm厚度明显增高(P0.05);与对照组相比,DM组角膜内皮CD和角膜6A%明显降低,CV明显升高(P0.05)。结论老年DM患者角膜内皮细胞形态结构和角膜厚度发生异常,对临床有指导意义。
[Abstract]:Objective to investigate the dynamic changes of corneal endothelial cell morphology and corneal thickness in elderly patients with diabetes mellitus (DM). Methods Twenty-eight patients (56 eyes) with type 2 diabetes mellitus (T2DM) were included in DM group (n = 28) and healthy volunteers (n = 56) were used as control group. The coefficient of variation (CV), mean density (CDT), hexagonal cell ratio (HCT), central corneal thickness (CCT) and external corneal thickness (1.5 mm and 3.0 mm) were measured and quantitatively analyzed in all subjects. Corneal endothelial cell images were taken and analyzed. Results compared with the control group, the thickness of CCT in DM group was significantly higher than that in DM group (1.5 mm and 3.0 mm), and the corneal endothelium CD and corneal 6A% in DM group were significantly lower than those in control group (P 0.05). Conclusion the abnormal morphology and corneal thickness of corneal endothelial cells in elderly DM patients are of guiding significance in clinical practice.
【作者单位】：福建医科大学附属第二医院眼科;
【基金】：泉州市医疗卫生领域指导性科技计划项目(No.2015QZZD12)
【分类号】：R587.2;R771.3

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