降浊定痛方联合秋水仙碱治疗痛风急性发作期的临床研究

发布时间：2018-04-29 20:22

  本文选题：降浊定痛方 + 秋水仙碱　； 参考：《中药药理与临床》2017年02期

【摘要】：目的:评价降浊定痛方联合小剂量秋水仙碱对痛风急性发作期患者的疗效。方法:将150例痛风患者随机分为治疗组(75例)与对照组(75例),分别口服降浊定痛方煎剂联合小剂量秋水仙碱及单药秋水仙碱,所有患者均口服碳酸氢钠片,疗程14天。观察患者症状严重程度积分、药物总有效率、血生化指标、以及血尿酸(BUA)、谷丙转氨酶(ALT)和血脂水平,并比较两药不良反应发生率。结果:与本组治疗前相比,两组症状严重程度积分均明显降低;两组药物总有效率无统计学差异;治疗2周后,两组患者血白细胞总数、中性粒细胞分类、血沉、CRP含量在治疗后均明显降低;但治疗组血尿酸、谷丙转氨酶、总胆固醇、甘油三脂显著降低,对照组在治疗后则无明显改善;与对照组比较,治疗组不良反应发生率率显著降低。结论:降浊定痛方联合小剂量秋水仙碱治疗对控制痛风患者急性期炎症状,疗效与秋水仙碱相当,但同时具有降血尿酸、降脂、保肝,安全性高的优点。
[Abstract]:Objective: to evaluate the curative effect of Jiangzhuodingtong decoction combined with low dose colchicine on patients with acute attack of gout. Methods: 150 patients with gout were randomly divided into treatment group (n = 75) and control group (n = 75). They were treated with Jiangzhuodingtong decoction combined with low-dose colchicine and single-drug colchicine respectively. All patients were treated with sodium bicarbonate for 14 days. The symptom severity score, total effective rate, blood biochemical index, serum uric acid BUAA, alt and serum lipids were observed, and the incidence of adverse reactions between the two drugs was compared. Results: compared with before treatment, the scores of symptom severity in the two groups were significantly decreased, there was no statistical difference in the total effective rate between the two groups, and after 2 weeks of treatment, the total number of white blood cells and neutrophils in the two groups were classified. The content of ESR CRP decreased significantly after treatment, but the serum uric acid, alanine aminotransferase, total cholesterol, triglyceride decreased significantly in the treatment group, but there was no significant improvement in the control group. The incidence rate of adverse reactions in the treatment group was significantly decreased. Conclusion: Jiangzhuodingtong prescription combined with low dose colchicine can control the symptoms of acute phlogistic in patients with gout. The curative effect is similar to that of colchicine, but it has the advantages of reducing blood uric acid, lowering fat, protecting liver and high safety.
【作者单位】： 河北大学附属医院;保定市第一中心医院;河北大学预防医学与卫生事业管理系;河北大学医学院药理教研室;河北大学附属医院中医科;
【分类号】：R589.7
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本文编号：1821411