白细胞亚型和甲状腺功能检测在甲状腺毒症鉴别诊断中的意义

发布时间：2018-04-30 15:23

本文选题：白细胞亚型 + 甲状腺功能　；参考：《吉林大学学报(医学版)》2017年06期

【摘要】：目的:探讨不同甲状腺毒症患者血白细胞亚型和甲状腺功能的差异,阐明血白细胞亚型和甲状腺功能检测鉴别诊断Graves病甲状腺毒症和破坏性甲状腺毒症的实用意义。方法:回顾性分析经临床和实验室检查确诊的33例Graves病患者和30例破坏性甲状腺毒症患者的中性粒细胞(Ne)、淋巴细胞(Ly)、嗜碱性粒细胞(Ba)、嗜酸性粒细胞(Eo)、单核细胞(Mo)、血清游离甲状腺素(FT4)、游离三碘甲状腺原氨酸(FT3)和甲状腺刺激激素(TSH)值;采用受试者工作曲线(ROC)评价有统计学意义的检查指标对Graves病和破坏性甲状腺毒症的鉴别诊断价值。结果:Graves病组患者血清Eo、FT4与FT3值和改良后的数据Eo/Mo、Eo×FT3/Mo均明显高于破坏性甲状腺毒症组(P0.05),而TSH和Mo值低于破坏性甲状腺毒症组(P0.05)。ROC曲线分析,Eo、Eo/Mo、Eo×FT3/Mo在2种疾病鉴别诊断中的灵敏度和特异度良好,最佳诊断界点分别为1.54、0.34和3.94。结论:Eo、Mo、TSH、FT3、FT4、Eo/Mo和Eo×FT3/Mo均可作为鉴别诊断2种疾病的依据,其中Eo、Eo/Mo和Eo×FT3/Mo对于Graves病与破坏性甲状腺毒症的鉴别诊断实用意义较大。
[Abstract]:Objective: to explore the difference of serum leukocyte subtypes and thyroid function in patients with different thyroid toxicosis, and to clarify the practical significance of differential diagnosis of Graves's disease with thyroid toxicity and thyroid function test. Methods: the neutrophil neutrophils, lymphocytes, basophil, eosinophils, monocytes and monocytes of 33 patients with Graves's disease and 30 patients with destructive thyrotoxicosis were analyzed retrospectively. Serum free thyroxine FT _ 4, free triiodothyronine FT _ 3 and thyroid stimulating hormone TSHs; The differential diagnosis of Graves disease and destructive thyrotoxicity was evaluated by using the working curve of subjects. Results the serum EoT _ 4 and FT3 values and the modified data of Eo / Mo-Eo 脳 FT3/Mo were significantly higher than those of the destructive thyrotoxicity group (P0.05), while the values of TSH and Mo were lower than that of the destructive Thyrotoxic patients (P0.05) .ROC curve analysis of EoEo / MoEo 脳 FT3/Mo in the differential diagnosis of two kinds of diseases Good sensitivity and specificity, The best diagnostic cutoff points were 1.54% 0.34 and 3.94 respectively. Conclusion Eo / Mo and Eo 脳 FT3/Mo can be used as the basis for differential diagnosis of two diseases. Among them, Eo / Mo and Eo 脳 FT3/Mo are of great practical significance in differential diagnosis of Graves disease and destructive thyroid disease.
【作者单位】：滨州医学院烟台附属医院内分泌科;山东省临沂市中医院内分泌科;
【基金】：山东省科技厅中青年科学家科研奖励基金资助课题(BS2010YY002);山东省科技厅自然科学基金资助课题(ZR2015HL029)
【分类号】：R581

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