帕金森病患者骨密度和血清25-羟维生素D浓度的研究

发布时间：2018-05-01 15:19

本文选题：帕金森病 + 维生素D　；参考：《南京医科大学学报(自然科学版)》2016年08期

【摘要】：目的:通过分析帕金森病患者与健康对照者骨密度(BMD)和血清25-羟维生素D(25-OH-Vit D)浓度,探索帕金森病患者骨折发生原因。方法:使用双能X线骨密度检测仪(DEXA)对帕金森病患者和健康体检者进行BMD测定,酶联免疫吸附试验检测血清25-OH-Vit D浓度。结果:帕金森病患者股骨颈T值、腰椎总T值明显低于对照组,差异有统计学意义(P0.01);帕金森组血清25-OH-Vit D浓度明显低于对照组,差异有统计学意义(P0.01);帕金森患者腰椎总T值、股骨颈T值、血清25-OH-Vit D浓度与帕金森HY分级之间的负性相关关系均无统计学意义。结论:帕金森病患者骨质疏松发生率高于对照组,血清25-OH-Vit D浓度低于对照组,帕金森患者骨折发生可能由骨密度下降和血清25-OH-Vit D浓度降低引起。
[Abstract]:Objective: to investigate the causes of fracture in Parkinson's disease patients by analyzing the concentration of bone mineral density (BMD) and serum 25-hydroxyvitamin D (25-OH-Vit D) in patients with Parkinson's disease (PD) and healthy controls. Methods: dual energy X-ray absorptiometry (DEXA) was used to detect BMD in Parkinson's disease patients and healthy controls. Serum 25-OH-Vit D concentration was detected by enzyme linked immunosorbent assay (Elisa). Results: the T value of femoral neck and total T value of lumbar vertebrae in Parkinson's disease patients were significantly lower than those in control group (P 0.01), the serum 25-OH-Vit D concentration in Parkinson's group was significantly lower than that in control group (P 0.01), the total T value of lumbar vertebrae in Parkinson's disease group was significantly lower than that in control group. There was no significant negative correlation between T value of femoral neck, serum 25-OH-Vit D concentration and Parkinson's HY grade. Conclusion: the incidence of osteoporosis in patients with Parkinson's disease is higher than that in the control group, and the serum 25-OH-Vit D level is lower than that in the control group. The fracture of Parkinson's disease may be caused by the decrease of bone mineral density and the decrease of serum 25-OH-Vit D concentration.
【作者单位】：南京医科大学第一附属医院老年神经科;无锡锡山人民医院神经内科;南京医科大学第一附属医院老年内分泌科;南京医科大学第一附属医院神经内科;
【基金】：江苏省干部保健课题(2012T50512)
【分类号】：R580;R742.5

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