金天格胶囊对老年高血压患者骨密度、骨代谢及骨硬化蛋白水平的影响

发布时间：2018-05-01 19:34

本文选题：高血压 + 骨质疏松　；参考：《中国骨质疏松杂志》2017年12期

【摘要】：目的探索老年高血压并骨质疏松患者口服金天格胶囊对骨密度及骨代谢指标的影响。方法选择2013年7月至2015年9月我院老年高血压并骨质疏松患者144例为研究对象,随机、双盲分为治疗组(n=72)和对照组(n=72)。治疗组患者口服金天格胶囊+钙剂,对照组口服钙剂。两组观察12个月,测定治疗前及治疗后12个月的血清骨钙素(OC)、血清Ⅰ型胶原C末端肽(s-CTX)、血清骨源性碱性磷酸酶(BAP)、血清骨硬化蛋白(SCL)和骨密度值(腰椎正位、股骨颈、前臂、股骨粗隆)。结果两组骨密度及骨代谢指标参数基线值比较,差异无统计学意义(P0.05)。治疗后12个月后,两组OC、BAP及腰椎正位、股骨颈、前臂、股骨粗隆的BMD显著增大,且s-CTX、SCL水平显著降低(P0.05);而治疗组治疗后OC、BAP、sCTX、SCL及腰椎正位、股骨颈、前臂、股骨粗隆的BMD改变显著优于对照组(P0.05)。结论口服金天格胶囊可以通过改变骨代谢和抑制SCL表达而提高高血压合并骨质疏松患者的骨密度。
[Abstract]:Objective to explore the effect of oral Jintian Capsule on bone mineral density and bone metabolism in elderly patients with hypertension and osteoporosis. Methods 144 cases of senile hypertension and osteoporosis in our hospital from July 2013 to September 2015 were selected and randomly divided into treatment group (n=72) and control group (n=72). The patients in the treatment group were taken orally with Jintian capsule. Serum osteocalcin (OC), serum collagen C terminal peptide (s-CTX), serum osteogenic alkaline phosphatase (BAP), serum osteosclerosis protein (SCL) and bone density value (lumbar vertebral position, femoral neck, forearm, thighbone trochanter) were measured in the two group for 12 months, and two groups of bone density and bone generation were observed. After 12 months after treatment, two groups of OC, BAP and lumbar vertebrae, the BMD of the femoral neck, forearm, and trochanter were significantly increased, and the s-CTX, SCL level was significantly decreased (P0.05) after 12 months of treatment, while OC, BAP, sCTX, SCL and lumbar vertebrae in the treatment group were significantly changed after treatment, and the BMD changes of the neck, forearm, and trochanter of the femur were significantly changed. It was better than the control group (P0.05). Conclusion oral Jintian Ge capsule can improve bone mineral density in patients with hypertension complicated with osteoporosis by changing bone metabolism and inhibiting SCL expression.

【作者单位】：上海市浦东新区周浦医院骨科;上海市浦东新区周浦医院检验科;
【基金】：上海市医学重点专科建设基金(ZK2015A14)
【分类号】：R544.1;R580

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