PTX-3在干燥综合征患者中的表达水平及其临床意义

发布时间：2018-05-01 21:25

本文选题：干燥综合征 + 肾小管损伤　；参考：《南京医科大学学报(自然科学版)》2016年11期

【摘要】：目的 :探讨正五聚素-3(pentraxin 3,PTX3)在干燥综合征中的临床意义。方法 :ELISA方法检测52例干燥综合征患者和15例健康体检者血浆PTX3水平,并分析了PTX3与干燥综合征患者临床指标的相关性。结果:1血浆PTX3水平变化:干燥综合征患者血浆PTX3水平[(1.492±0.018)ng/m L]显著高于健康对照组[(1.403±0.019)ng/ml],其中肾小管功能异常患者血浆PTX3水平[(1.573±0.019)ng/m L]显著高于无肾小管功能异常患者[(1.418±0.003)ng/m L](P0.01)。2在干燥综合征合并肾小管功能异常的患者中,血浆PTX3水平与尿可滴定酸及尿铵离子水平呈显著负相关(P0.05),而与炎症相关指标C反应蛋白、血沉无明显相关性,与免疫学指标Ig A、Ig G、Ig M、SS相关抗体、类风湿因子无相关关系。3对于干燥综合征合并肾小管功能异常的诊断效能PTX3与尿β2微球蛋白相当,PTX的ROC曲线下面积(AUC)为0.702(95%CI:0.593~0.811),与尿β2微球蛋白(AUC:0.705,95%CI:0.567~0.843)无明显差异。结论:PTX3可能作为干燥综合征患者肾小管间质损伤的生物学标志物。
[Abstract]:Objective: to investigate the clinical significance of pentraxin 3 pentraxin 3 PTX 3 in Sjogren's syndrome. Methods the plasma PTX3 levels in 52 patients with Sjogren's syndrome (SSS) and 15 healthy controls were measured by using the 10% Elisa. The correlation between PTX3 and the clinical indexes of Sjogren's syndrome (SSS) was analyzed. Results the plasma PTX3 level in Sjogren's syndrome patients [1.492 卤0.018)ng/m L] was significantly higher than that in healthy controls [1.403 卤0.019)ng/ml], and the plasma PTX3 level in patients with renal tubular dysfunction [1.573 卤0.019)ng/m L] was significantly higher than that in patients without tubule dysfunction [1.418 卤0.003)ng/m L] P 0.01.2 In patients with Sjogren's syndrome complicated with abnormal renal tubule function, Plasma PTX3 level was negatively correlated with urinary titratable acid and urine ammonium ion level, but not with inflammation related index C reactive protein and erythrocyte sedimentation rate (ESR). There was no correlation between rheumatoid factor and RHD in the diagnosis of Sjogren's syndrome with renal tubule dysfunction. The area under the ROC curve of PTX3 and 尾 2 microglobulin was 0. 702 95% CI: 0. 593 + 0. 811%, which had no significant difference from that of urine 尾 2 microglobulin (IC: 0. 705) and urine 尾 2 microglobulin (CI: 0. 5670. 843). Conclusion 1: PTX 3 may be a biomarker of renal tubulointerstitial injury in patients with Sjogren's syndrome.
【作者单位】：南京医科大学第一附属医院肾脏科;南京医科大学第一附属医院风湿免疫科;
【基金】：国家自然科学基金(81302575) 江苏省自然科学基金(BK20131028)
【分类号】：R593.2

【相似文献】