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新确诊的2型糖尿

发布时间:2018-05-02 20:46

  本文选题:认知功能障碍 + 脑白质微结构 ; 参考:《山东医药》2017年43期


【摘要】:目的探讨新确诊的2型糖尿病(T2DM)和糖耐量减低(IGT)患者是否存在认知功能障碍和脑白质微结构改变及二者是否有关。方法新确诊的T2DM患者20例(T2DM组)、新确诊的IGT患者18例(IGT组)、正常人17例(正常组),接受蒙特利尔量表(Mo CA)评分及脑白质磁共振弥散张量成像(DTI)检查[得到各向异性(FA)值],分析Mo CA评分与FA值的相关性。结果 T2DM组、IGT组、正常组的Mo CA评分分别为(24.78±2.42)、(26.12±1.47)、(27.16±2.21)分;组间相比,P0.01;T2DM组与IGT组、正常组相比,P均0.05;IGT组与正常组相比,P0.05。T2DM组、IGT组、正常组的左侧脑白质FA值(FAl)分别为0.457 8±0.020 1、0.472 3±0.018 2、0.487 6±0.020 0;组间相比,P0.01;T2DM组与IGT组、正常组相比,P均0.05;IGT组与正常组相比,P0.05。T2DM组、IGT组、正常组的右侧脑白质FA值(FAr)分别为0.469 8±0.019 3、0.481 7±0.036 8、0.492 7±0.022 4;组间相比,P0.05;T2DM组与IGT组、正常组相比,P均0.05;IGT组与正常组相比,P0.05。T2DM组Mo CA评分与FAl呈正相关(r=0.432,P0.05),与FAr无相关关系(r=0.605,P0.05)。结论新确诊的T2DM患者可能已经存轻度认知功能障碍及脑白质微结构改变,而新确诊的IGT患者的认知功能和脑白质微结构可能尚未出现改变;新确诊的T2DM患者左侧脑白质微结构的改变可能对认知功能下降有一定影响。
[Abstract]:Objective to investigate whether the patients with newly diagnosed type 2 diabetes mellitus (T2DM) and impaired glucose tolerance (IGT) have cognitive impairment and white matter microstructural changes and whether there is a correlation between the two. Methods Twenty newly diagnosed T2DM patients with T2DM, 18 patients with newly diagnosed IGT and 17 normal subjects (normal group, received the Montreal scale of Mo CA) and white matter magnetic resonance diffusion Zhang Liang imaging (DTI) were examined. The correlation between Mo CA score and FA value was analyzed. Results the scores of Mo CA in T2DM group and normal group were 24.78 卤2.42, 26.12 卤1.47, 27.16 卤2.21, P 0.01 and IGT, respectively. The FA values of left white matter in normal group were 0.457 8 卤0.020 1,0.472 3 卤0.018 2n 0.487 6 卤0.020 0, respectively, compared with P0.01T2DM group and IGT group, and the comparison between normal group and normal group was compared with that of normal group, and the difference between normal group and normal group was significantly higher than that in normal group (P < 0.05), and that in normal group was significantly higher than that in normal group (P < 0.05). The FA value of right white matter in normal group was 0.469 8 卤0.019 3 卤0 481 7 卤0.036 8 卤0 492 7 卤0.022 4 respectively, and there was no significant correlation between normal group and normal group (P 0. 05%) and normal group (P 0. 05%, P < 0 05). There was a positive correlation between Mo CA score and FAl in normal group (P 0. 05) and no correlation with FAr (r 0. 605 P 0. 05). Conclusion the newly diagnosed patients with T2DM may already have mild cognitive impairment and white matter microstructural changes, while the newly diagnosed IGT patients may not have any changes in cognitive function and white matter microstructure. The changes of left white matter microstructures in newly diagnosed T2DM patients may have an effect on cognitive impairment.
【作者单位】: 郑州大学第二附属医院;
【基金】:河南省高等学校重点科研项目(17A320039)
【分类号】:R587.2

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